pan ECA Antibody (MECA-32): sc-19603

pan ECA Antibody (MECA-32) is a rat monoclonal IgG2a antibody that detects pan ECA proteins of mouse origin by immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-pan ECA antibody (MECA-32) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. pan ECA proteins play a crucial role in the formation and maintenance of the vascular network, which is essential for proper blood circulation and nutrient delivery throughout the body. These proteins are primarily located on the surface of endothelial cells, which line blood vessels and are vital for regulating vascular permeability and inflammation. pan ECA protein expression is particularly significant during embryonic development, as these proteins facilitate the formation of new blood vessels through a process known as angiogenesis. pan ECA (MECA-32) antibody exhibits high specificity for mouse endothelium in both embryonic and mature tissues, marking pan ECA (MECA-32) monoclonal antibody as a valuable tool for studying vascular biology. Notably, MECA-32 antigen is expressed on most endothelial cells in the embryonic and adult mouse, with the exception of certain tissues such as the brain, skeletal muscle, and cardiac muscle, where expression is selectively regulated. In the brain, MECA-32 presence is inversely related to the maturation of the blood-brain barrier, highlighting MECA-32′s importance in vascular differentiation and function.

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pan ECA Antibody (MECA-32) References:

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-pan ECA Antibody (MECA-32) has 17 citations in a variety of scientific publications.

Primary antibodies like Anti-pan ECA Antibody (MECA-32) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

pan ECA Antibody (MECA-32) Specifications

Alternate Product Name: pan ECA

Product Clone Name: MECA-32

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: pan ECA

Epitope Species: rat

Product Reactivity/Detection: a dimer of subunits expressed on endothelial cells in embryonic and adult mouse, with the exception of cardicac muscle, skeletal muscle and brain

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 17 citations in various scientific publications

Available Conjugates/Forms for pan ECA Antibody (MECA-32): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin