pan CEA Antibody (HEA19): sc-73367

Pan CEA Antibody (HEA19) is a mouse monoclonal IgG1 antibody that detects carcinoembryonic antigen (CEA) in human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-CEA antibody (HEA19) is particularly valuable in clinical diagnostics, as CEA serves as a crucial tumor marker for various carcinomas, aiding in monitoring cancer progression and treatment response. CEA (HEA19) monoclonal antibody recognizes proteins primarily located on the cell surface, where CEA plays a significant role in cell adhesion and signaling, essential for maintaining tissue architecture and facilitating communication between cells. CEA (HEA19) antibody targets proteins whose altered expression can influence tumor behavior, including metastasis and immune evasion, making CEA a key target for therapeutic interventions. CEA belongs to the CEACAM family, involved in diverse biological processes such as angiogenesis and immune modulation, further underscoring CEA′s importance in both normal physiology and disease states. Human CEACAM proteins are encoded by genes clustered on chromosome 19, highlighting their evolutionary conservation and relevance in human health.

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pan CEA Antibody (HEA19) References:

1. Value of carcinoembryonic antigen (CEA) and cholesterol assays of ascitic fluid in cases of inconclusive cytology.  |  Gulyás, M., et al. 2001. J Clin Pathol. 54: 831-5. PMID: 11684715
2. Diminishing impact of preoperative carcinoembryonic antigen (CEA) in prognosis of Dukes' C colorectal cancer.  |  Katoh, H., et al. 2008. Anticancer Res. 28: 1933-41. PMID: 18630484
3. Phylogenetic discordance of human and canine carcinoembryonic antigen (CEA, CEACAM) families, but striking identity of the CEA receptors will impact comparative oncology studies.  |  Weichselbaumer, M., et al. 2011. PLoS Curr. 3: RRN1223. PMID: 21436956
4. Immunohistochemical localization of carcinoembryonic antigen (CEA) in salivary gland tumors.  |  Alfaro, M. and Carrozza, M. 1990. Oral Surg Oral Med Oral Pathol. 69: 479-82. PMID: 2158032
5. Immunohistochemical study of carcinoembryonic antigen (CEA) in lung carcinoma by five monoclonal antibodies.  |  Hiraoka, K. and Horie, A. 1988. J UOEH. 10: 237-46. PMID: 2845551
6. Serum-derived carcinoembryonic antigen (CEA) activates fibroblasts to induce a local re-modeling of the extracellular matrix that favors the engraftment of CEA-expressing tumor cells.  |  Abdul-Wahid, A., et al. 2018. Int J Cancer. 143: 1963-1977. PMID: 29756328
7. Comparative Study of Blood, Tissue and Serum Levels of Carcinoembryonic Antigen (CEA) Detection in Breast Cancer.  |  Moazzezy, N., et al. 2019. Asian Pac J Cancer Prev. 20: 2979-2985. PMID: 31653144
8. Immunohistochemical observations of carcinoembryonic antigen (CEA) and CEA-related substances in normal and neoplastic pancreas. Pitfalls and caveats in CEA immunohistochemistry.  |  Tsutsumi, Y., et al. 1984. Am J Clin Pathol. 82: 535-42. PMID: 6388311
9. Differential immunocytochemical localization of tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA) in breast cancer.  |  Björklund, V. and Björklund, B. 1983. Cancer Detect Prev. 6: 193-8. PMID: 6883380
10. Reducing interference from heterophilic antibodies in a two-site immunoassay for carcinoembryonic antigen (CEA) by using a human/mouse chimeric antibody to CEA as the tracer.  |  Kuroki, M., et al. 1995. J Immunol Methods. 180: 81-91. PMID: 7897248

The preferred CEACAM5 antibody is CEACAM5 Antibody (CI-P83-1): sc-23928.