Date published: 2025-10-31

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Pamoic acid (CAS 130-85-8)

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Alternate Names:
1,1′-Methylene-bis(2-hydroxy-3-naphthoic acid); 4,4′-Methylenebis(3-hydroxy-2-naphthoic acid)
Application:
Pamoic acid is A naphthoic acid derivative
CAS Number:
130-85-8
Purity:
≥96%
Molecular Weight:
388.37
Molecular Formula:
C23H16O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Pamoic acid, a dicarboxylic acid derivative of naphtoic acid, has attracted significant interest in scientific research due to its unique chemical properties and diverse applications. Its mechanism of action primarily revolves around its ability to form stable complexes with metal ions, particularly transition metals like copper and zinc. These metal complexes exhibit distinct spectroscopic properties, making pamoic acid a valuable tool in analytical chemistry for metal ion detection and quantification. Moreover, pamoic acid has been explored in material science for its role as a ligand in the synthesis of metal-organic frameworks (MOFs). These porous materials, composed of metal ions or clusters coordinated with organic ligands like pamoic acid, possess high surface areas and tunable structures, making them promising candidates for gas storage, separation, and catalysis. In addition, pamoic acid-based MOFs have shown potential applications in drug delivery, where the porous structure allows for the encapsulation and controlled release of chemical agents. Furthermore, research efforts continue to investigate novel synthetic routes and functionalization strategies to expand the utility of pamoic acid and its derivatives in various scientific fields, ranging from chemistry to materials science.


Pamoic acid (CAS 130-85-8) References

  1. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.  |  Zhao, P., et al. 2010. Mol Pharmacol. 78: 560-8. PMID: 20826425
  2. Investigation of salt formation between memantine and pamoic acid: Its exploitation in nanocrystalline form as long acting injection.  |  Mittapelly, N., et al. 2016. Eur J Pharm Biopharm. 101: 62-71. PMID: 26850817
  3. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages.  |  Sharmin, O., et al. 2020. Sci Rep. 10: 9400. PMID: 32523084
  4. Molecular disruption of DNA polymerase β for platinum sensitisation and synthetic lethality in epithelial ovarian cancers.  |  Ali, R., et al. 2021. Oncogene. 40: 2496-2508. PMID: 33674744
  5. Preparation and Release Profiles in Vitro/Vivo of Galantamine Pamoate Loaded Poly (Lactideco-Glycolide) (PLGA) Microspheres.  |  Du, L., et al. 2020. Front Pharmacol. 11: 619327. PMID: 33762929
  6. GPR35 in Intestinal Diseases: From Risk Gene to Function.  |  Kaya, B., et al. 2021. Front Immunol. 12: 717392. PMID: 34790192
  7. Modulation of muscle redox and protein aggregation rescues lethality caused by mutant lamins.  |  Coombs, GS., et al. 2021. Redox Biol. 48: 102196. PMID: 34872044
  8. Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor.  |  Divorty, N., et al. 2022. J Biol Chem. 298: 101655. PMID: 35101446
  9. Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.  |  Wyant, GA., et al. 2022. Science. 377: 621-629. PMID: 35926043
  10. Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias.  |  Schihada, H., et al. 2022. J Biol Chem. 298: 102328. PMID: 35933013
  11. Pamoic acid is an inhibitor of HMGB1·CXCL12 elicited chemotaxis and reduces inflammation in murine models of Pseudomonas aeruginosa pneumonia.  |  De Leo, F., et al. 2022. Mol Med. 28: 108. PMID: 36071400
  12. Jwa participates the maintenance of intestinal epithelial homeostasis via ERK/FBXW7-mediated NOTCH1/PPARγ/STAT5 axis and acts as a novel putative aging related gene.  |  Li, X., et al. 2022. Int J Biol Sci. 18: 5503-5521. PMID: 36147468
  13. Post-Injection Delirium/Sedation Syndrome: A Case Report and 2-Year Follow-Up.  |  Podgorná, G., et al. 2022. Am J Case Rep. 23: e937579. PMID: 36245104
  14. Photophysical and Fluorescence Nitroaromatic Sensing Properties of Methylated Derivative of a Pamoic Acid Ester.  |  Bal, M., et al. 2023. J Fluoresc. 33: 77-90. PMID: 36251202

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Pamoic acid, 100 g

sc-212523
100 g
$90.00