Molecular structure of Pamidronate disodium salt, CAS Number: 57248-88-1
Pamidronate disodium salt (CAS 57248-88-1)
Alternate Names:
(3-Amino-1-hydroxypropylidene)bisphosphonic Acid Disodium; Pamidronic Acid Sodium Salt
Application:
Pamidronate disodium salt is a farnesyl diphosphate synthase inhibitor
CAS Number:
57248-88-1
Molecular Weight:
279.03
Molecular Formula:
C3H9NO7P2Na2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pamidronate disodium salt hydrate is a bisphosphonate compound, which inhibits farnesyl diphosphate synthase and bone resorption. Studies suggest that Pamidronate disodium salt hydrate stimulates polymorphonuclear leukocyte and platelet derived nitric oxide production. It is believed that this nitric oxide production can lead to a negative feedback mechanism, which could restrict the inflammatory process and reduce bone resorption. Furthermore, bisphosphonates induce endothelial cell death, cancer cell apoptosis, and nuclear factor-κB pathway activation, via the endothelial protein C receptor.
Pamidronate disodium salt (CAS 57248-88-1) References
- Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. | Dunford, JE., et al. 2001. J Pharmacol Exp Ther. 296: 235-42. PMID: 11160603
- High concentrations of pamidronate in bone weaken the mechanical properties of intact femora in a rat model. | Yang, KH., et al. 2007. Yonsei Med J. 48: 653-8. PMID: 17722238
- Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-κB pathways. | Seol, JW., et al. 2011. Int J Mol Med. 27: 835-40. PMID: 21424111
- Prediction of bioavailability of selected bisphosphonates using in silico methods towards categorization into a biopharmaceutical classification system. | Biernacka, J., et al. 2013. Acta Pol Pharm. 70: 877-82. PMID: 24147367
- Adaptable Hydrogels Mediate Cofactor-Assisted Activation of Biomarker-Responsive Drug Delivery via Positive Feedback for Enhanced Tissue Regeneration. | Zhang, K., et al. 2018. Adv Sci (Weinh). 5: 1800875. PMID: 30581701
- Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia. | Gadelha, APR., et al. 2020. Parasit Vectors. 13: 168. PMID: 32248823
- Surface decoration of development-inspired synthetic N-cadherin motif via Ac-BP promotes osseointegration of metal implants. | Zhu, M., et al. 2021. Bioact Mater. 6: 1353-1364. PMID: 33210028
- Combinatorial approach for improved production of whole-cell 3-aminopropionic acid in recombinant Bacillus megaterium: codon optimization, gene duplication and process optimization. | Tadi, SRR., et al. 2021. 3 Biotech. 11: 333. PMID: 34221804
- Risedronate and Methotrexate Are High-Affinity Inhibitors of New Delhi Metallo-β-Lactamase-1 (NDM-1): A Drug Repurposing Approach. | Muteeb, G., et al. 2022. Molecules. 27: PMID: 35209073
- In vitro Effect of Geranylgeraniol (GGOH) on Bisphosphonate-Induced Cytotoxicity of Oral Mucosa Cells. | Rattanawonsakul, K., et al. 2022. Front Oral Health. 3: 892615. PMID: 35795156
Inhibitor of:
FDPS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pamidronate disodium salt, 10 mg | sc-272006 | 10 mg | $151.00 | |||
Pamidronate disodium salt, 100 mg | sc-272006A | 100 mg | $390.00 |