Molecular structure of Palmitoyl-N-isopropylamide, CAS Number: 189939-61-5
Palmitoyl-N-isopropylamide (CAS 189939-61-5)
Application:
Palmitoyl-N-isopropylamide is a fatty acid amide hydrolase (FAAH) inhibitor
CAS Number:
189939-61-5
Molecular Weight:
297.52
Molecular Formula:
C19H39NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Palmitoyl-N-isopropylamide is an inhibitor of the FAAH (fatty acid amide hydrolase). Studies suggest that Palmitoyl-N-isopropylamide shows minimal binding to CB1 and CB2 receptors. In addition, Palmitoyl-N-isopropylamide inhibits [3H]-fatty acid amide anandamide (AEA) uptake into c6 and RBL-2H3 cells. Palmitoyl-N-isopropylamide functions similarly to AM-404 (sc-200363) in inhibiting the formation of [3H]-ethanolamine from [3H]-AEA. Researchers suggest that Palmitoyl-N-isopropylamide can be a useful template for designing compounds that reduce the cellular accumulation and metabolism of AEA because the compound does not affect CB1 and CB2 receptors.
Palmitoyl-N-isopropylamide (CAS 189939-61-5) References
- Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. | Jonsson, KO., et al. 2001. Br J Pharmacol. 133: 1263-75. PMID: 11498512
- The palmitoylethanolamide family: a new class of anti-inflammatory agents? | Lambert, DM., et al. 2002. Curr Med Chem. 9: 663-74. PMID: 11945130
- 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism. | Smart, D., et al. 2002. Br J Pharmacol. 136: 452-8. PMID: 12023948
- Cellular transport of anandamide, 2-arachidonoylglycerol and palmitoylethanolamide--targets for drug development? | Fowler, CJ. and Jacobsson, SO. 2002. Prostaglandins Leukot Essent Fatty Acids. 66: 193-200. PMID: 12052035
- AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. | Jonsson, KO., et al. 2003. Arch Toxicol. 77: 201-7. PMID: 12698235
- The cannabinoid CB2 receptor selective agonist JWH133 reduces mast cell oedema in response to compound 48/80 in vivo but not the release of beta-hexosaminidase from skin slices in vitro. | Jonsson, KO., et al. 2006. Life Sci. 78: 598-606. PMID: 16111718
- Fatty acid amide hydrolase controls mouse intestinal motility in vivo. | Capasso, R., et al. 2005. Gastroenterology. 129: 941-51. PMID: 16143133
- Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors. | Vandevoorde, S. 2008. Curr Top Med Chem. 8: 247-67. PMID: 18289091
- Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT). | Bashashati, M., et al. 2017. Neurogastroenterol Motil. 29: PMID: 28695708
- Determination of Tissue Distribution of Alisol G, a CB1R Antagonist, in Rats by Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry. | Gao, Chen-Yu, et al. 2020. Pharmaceutical Fronts. 2.04: e179-e187.
Inhibitor of:
FAAH.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Palmitoyl-N-isopropylamide, 5 mg | sc-203177 | 5 mg | $56.00 |