Palmitoyl-DL-carnitine chloride (CAS 6865-14-1)
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Palmitoyl-DL-carnitine chloride is a long-chain acylcarnitine specific (PKC) protein kinase C inhibitor which also inhibits the enhanced transformation of 12-Otetra decanoyl phorbol-13-acetate (TPA) in BALB/3T3 cells. In addition, Palmitoyl-DL-carnitine chloride is a well known intermediate of fatty acid oxidation in mitochondria. Also, studies suggest that Palmitoyl-DL-carnitine chloride adjusts high-energy phosphates and free fatty acids in the heart. Furthermore, Palmitoyl-DL-carnitine chloride can increase erythroid colony formation in culture. Alternate studies indicate that Palmitoyl-DL-carnitine chloride can cause a reduction in Ca2+ currents in dorsal root ganglion neurons via Ca2+-induced Ca2+ release from intracellular stores or possibly direct interaction of Palmitoyl-DL-carnitine chloride with Ca2+ stores. Also Palmitoyl-DL-carnitine chloride can suppress calcium signal transduction in endothelial cells.
Palmitoyl-DL-carnitine chloride (CAS 6865-14-1) References
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- Palmitoyl-L-carnitine modifies the function of vascular endothelium. | Inoue, N., et al. 1994. Cardiovasc Res. 28: 129-34. PMID: 7509258
- Palmitoyl-L-carnitine acts like ouabain on voltage, current, and contraction in guinea pig ventricular cells. | Shen, JB. and Pappano, AJ. 1995. Am J Physiol. 268: H1027-36. PMID: 7900857
- Effect of membrane incorporation of 1-palmitoylcarnitine on surface charge of human erythrocytes. | Gruver, C. and Pappano, AJ. 1993. J Mol Cell Cardiol. 25: 1275-84. PMID: 8263958
- Activation and inhibition of reconstituted cardiac L-type calcium channels by palmitoyl-L-carnitine. | Liu, QY. and Rosenberg, RL. 1996. Biochem Biophys Res Commun. 228: 252-8. PMID: 8920902
- Palmitoyl-L-carnitine modifies the myocardial levels of high-energy phosphates and free fatty acids. | Xiao, CY., et al. 1997. Basic Res Cardiol. 92: 320-30. PMID: 9486353
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Palmitoyl-DL-carnitine chloride, 100 mg | sc-203176 | 100 mg | $104.00 | |||
Palmitoyl-DL-carnitine chloride, 500 mg | sc-203176A | 500 mg | $437.00 |