Molecular structure of Palmitic Acid, CAS Number: 57-10-3
Palmitic Acid (CAS 57-10-3)
See product citations (2)
Alternate Names:
Hexadecanoic Acid
Application:
Palmitic Acid is a saturated fatty acid that targets proteins to cell membranes
CAS Number:
57-10-3
Purity:
≥98%
Molecular Weight:
256.42
Molecular Formula:
C16H32O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Palmitic Acid, a 16 carbon saturated fatty acid, has been reported to target proteins to cell membranes. This compound has been found to promote triglyceride accumulation and also affect cell viability. Triglyceride accumulation in goose hepatocytes shows the ability to induce apoptosis. Mechanistic studies show that Palmitic Acid has also demonstrated the ability to induce opening of Ca2+-dependent pores in plasma membranes of red blood cells which will eventually lead to lysis of the cells. Additional studies suggest that saturated fatty acids can induce the expression of Cox-2 and NFkappaB (nuclear factor kappaB) activation.
Palmitic Acid (CAS 57-10-3) References
- Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. | Lee, JY., et al. 2001. J Biol Chem. 276: 16683-9. PMID: 11278967
- Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. | Ricchi, M., et al. 2009. J Gastroenterol Hepatol. 24: 830-40. PMID: 19207680
- Palmitic acid induces the opening of a Ca2+-dependent pore in the plasma membrane of red blood cells: the possible role of the pore in erythrocyte lysis. | Belosludtsev, KN., et al. 2010. J Membr Biol. 237: 13-9. PMID: 20835705
- Effects of palmitic acid on lipid metabolism homeostasis and apoptosis in goose primary hepatocytes. | Pan, Z., et al. 2011. Mol Cell Biochem. 350: 39-46. PMID: 21152956
- Palmitic Acid and Health: Introduction. | Agostoni, C., et al. 2016. Crit Rev Food Sci Nutr. 56: 1941-2. PMID: 25764181
- [Comparison of effects of oleic acid and palmitic acid on lipid deposition and mTOR / S6K1 / SREBP-1c pathway in HepG2 cells]. | Zhou, YP., et al. 2018. Zhonghua Gan Zang Bing Za Zhi. 26: 451-456. PMID: 30317760
- Loss of p53 Sensitizes Cells to Palmitic Acid-Induced Apoptosis by Reactive Oxygen Species Accumulation. | Yu, G., et al. 2019. Int J Mol Sci. 20: PMID: 31842349
- Palmitic Acid Promotes Virus Replication in Fish Cell by Modulating Autophagy Flux and TBK1-IRF3/7 Pathway. | Yu, Y., et al. 2020. Front Immunol. 11: 1764. PMID: 32849631
- Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1. | Rampersaud, AM., et al. 2020. Mol Hum Reprod. 26: 850-865. PMID: 32898274
- Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma. | Amine, H., et al. 2021. Sci Rep. 11: 5427. PMID: 33686181
- Palmitic acid inhibits prostate cancer cell proliferation and metastasis by suppressing the PI3K/Akt pathway. | Zhu, S., et al. 2021. Life Sci. 286: 120046. PMID: 34653428
- Palmitic Acid Promotes Lung Metastasis of Melanomas via the TLR4/TRIF-Peli1-pNF-κB Pathway. | Zhang, X., et al. 2022. Metabolites. 12: PMID: 36422271
- Assessment of palmitic acid toxicity to animal hearts and other major organs based on acute toxicity, network pharmacology, and molecular docking. | Lv, L., et al. 2023. Comput Biol Med. 158: 106899. PMID: 37058761
- Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae. | Dietzen, DJ., et al. 1995. J Biol Chem. 270: 6838-42. PMID: 7896831
- N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4. | Topinka, JR. and Bredt, DS. 1998. Neuron. 20: 125-34. PMID: 9459448
Inhibitor of:
AMPKγ3, CKAP4, DYX2_D130043K22Rik, GLIPR1L1, LCE3E, Lipin-1, Lipin-3, MBOAT4, PCDHB3, Peroxin 11α, PHKA2, PM20D1, RETSAT, RNF13, RPE, TMEM202, UCP2, UNC119B, ZDHHC, ZDHHC23, ZNF184, and ZNF729.Activator of:
δ-FR, 1500002O20Rik, 1700008B15Rik, AASDHPPT, ACAD-9, ACBD5, ACCα, ACOT2, ACOT4, ACSL4, ACSL5, ACSVL1, ACSVL6, ADRP, AGPS, AI747699, Angptl4, apoAL, ARV1, ASC, AUP1, Aytl1b, BC020002, BIP, BLVRB, Brn-3a, BSA, Caveolin-1, CD1E, CD300LD, CD36, CDS1, Ces1c, CIDE-B, CIDE-C, COX1, CPS2, CPTI-L, CRBP II, CREBRF, Cryopyrin, CTRP9B, CYB5R3, CYP4F22, cytochrome b5 type B, D8S2298E, Dbil5, DDHD2, DECR2, DGAT1, DGAT2, DGAT2L6, DHRS1, DSCR 5, EG436008, eIF4E, ELOVL2, ELOVL4, ELOVL5, ELOVL6, Embigin, ETFDH, Ethanolamine kinase 2, FABP12, FACL5, FAR1, FAR2, Fatty Acid Synthase, FNDC8, G2A, GCS-α-1, GFAT2, GLI-2, GLTP, GLTPD1, GLULD1, Glutamate Dehydrogenase, Glycophorin A, GNPAT, GPAM, GPAT2, GPD1L, GPR119, GPR40, GUP1, Hep C E2, Hep C NS4a, HLCS, HM74B, HNF-1β, HNF-3α, I-FABP, ICE-LAP6, Influenza B, KCTD5, Keratin 40, KIAA0247, L-Glycerol-3-Phosphate Oxidase, LASS4, LASS5, LAT2, LOC730005, LPAAT-ε, LPCAT1, LPGAT1, LRAT, LYPLA1, LYPLAL1, LYRM7, MBOAT5, MIPP, MOAP1, MondoA, Monoglyceride Lipase, MPG1, Mtch2, Mycobacterium avium, NALP2, NCB5OR, Neuregulin-4, neutral ceramidase, NMT1, O-GlcNAc transferase, OCTN3, Olfr517, Olfr518, ORMDL3, P. falciparum infected RBCs, PAcP, PC-PLD5, PCMTD1, PCYT2, PDK2, Peroxin 19, Peroxin 6, Pex14p, Pex7p, PHLDA3, PHLPPL, PI 3-kinase p101, PIG-preY, PIG-V, PIP2, PLA2G4B, Plb1, Pmp34, PPT2, PSS2, PTP1B, PTPLB, Rarres1, RDH11, RDH12, RDH14, RDH7, RDHE2, Reg II, REG IIIα, RIP5, RNF17, SAA1, SAAL1, saposin, SCD1, secretin, Selenoprotein K, SERINC1, Six6, SLC25A46, SMS2, SOAT2, SPP, SPTSSA, SREBP-1, StARD10, StARD7, StARD9, SUMO-3, Synip, SZT2, T-cadherin, Tap42, TDE2L, THEGL, THEM5, TMEM26, TRB-3, TRIM11, TTC34, TTP-α, UGCG, UGT8, VDAC1, YY1, ZADH1, ZDHHC11B, ZDHHC12, ZDHHC5, ZDHHC8, and ZNF439.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Palmitic Acid, 25 g | sc-203175 | 25 g | $112.00 | |||
Palmitic Acid, 100 g | sc-203175A | 100 g | $280.00 |