Molecular structure of Paliperidone, CAS Number: 144598-75-4
Paliperidone (CAS 144598-75-4)
See product citations (1)
Alternate Names:
9-Hydroxyrisperidone
Application:
Paliperidone is a serotonin (5-HT2) receptor antagonist and D2DR inhibitor
CAS Number:
144598-75-4
Purity:
≥98%
Molecular Weight:
426.48
Molecular Formula:
C23H27FN4O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Paliperidone is a SR (5-HT2) receptor antagonist and D2DR inhibitor.
Paliperidone (CAS 144598-75-4) References
- Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates. | Kerr, KM., et al. 2001. J Biol Chem. 276: 8657-64. PMID: 11121420
- High throughput physicochemical profiling for drug discovery. | Kerns, EH. 2001. J Pharm Sci. 90: 1838-58. PMID: 11745742
- The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. | Doran, A., et al. 2005. Drug Metab Dispos. 33: 165-74. PMID: 15502009
- Pharmacokinetic drug evaluation of paliperidone in the treatment of schizoaffective disorder. | Macaluso, M., et al. 2017. Expert Opin Drug Metab Toxicol. 13: 871-879. PMID: 28675307
- Paliperidone extended-release in the short- and long-term treatment of schizophrenia. | Valsecchi, P., et al. 2019. Riv Psichiatr. 54: 43-58. PMID: 30985829
- The preclinical discovery and development of paliperidone for the treatment of schizophrenia. | Wesołowska, A., et al. 2020. Expert Opin Drug Discov. 15: 279-292. PMID: 31661992
- Risperidone- and paliperidone-induced hepatotoxicity: Case report and review of literature. | Khorassani, F., et al. 2020. Am J Health Syst Pharm. 77: 1578-1584. PMID: 32699878
- Paliperidone-Associated Sialorrhea: A Case Report With Review of Current Literature. | Burk, BG., et al. J Clin Psychopharmacol. 42: 480-484. PMID: 35943409
- Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay. | Tiberghien, F. and Loor, F. 1996. Anticancer Drugs. 7: 568-78. PMID: 8862725
- Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes. | Kansy, M., et al. 1998. J Med Chem. 41: 1007-10. PMID: 9544199
Inhibitor of:
D2DR, and SR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Paliperidone, 25 mg | sc-204828 | 25 mg | $125.00 | |||
Paliperidone, 100 mg | sc-204828A | 100 mg | $300.00 |