Molecular structure of PALDA, CAS Number: 136181-87-8
PALDA (CAS 136181-87-8)
Application:
PALDA is an endogenous fatty acid dopamide
CAS Number:
136181-87-8
Molecular Weight:
391.60
Molecular Formula:
C24H41NO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PALDA is an endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. PALDA is inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). PALDA additionally potentiates TRPV1-mediated effects of NADA and lowers EC50 from ~ 90 to ~ 30 nM.
PALDA (CAS 136181-87-8) References
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- The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. | Cherukuri, DP., et al. 2007. Exp Cell Res. 313: 2969-79. PMID: 17631291
- Lubiprostone targets prostanoid EP₄ receptors in ovine airways. | Cuthbert, AW. 2011. Br J Pharmacol. 162: 508-20. PMID: 20883477
- Characterization of the EP receptor subtype that mediates the inhibitory effects of prostaglandin E2 on IgE-dependent secretion from human lung mast cells. | Kay, LJ., et al. 2013. Clin Exp Allergy. 43: 741-51. PMID: 23786281
- Possible involvement of brain prostaglandin E2 and prostanoid EP3 receptors in prostaglandin E2 glycerol ester-induced activation of central sympathetic outflow in the rat. | Shimizu, T., et al. 2014. Neuropharmacology. 82: 19-27. PMID: 24657150
- EP2 and EP4 receptors mediate PGE2 induced relaxation in murine colonic circular muscle: pharmacological characterization. | Martinez-Cutillas, M., et al. 2014. Pharmacol Res. 90: 76-86. PMID: 25461458
- The EP4 antagonist, L-161,982, induces apoptosis, cell cycle arrest, and inhibits prostaglandin E2-induced proliferation in oral squamous carcinoma Tca8113 cells. | Li, X., et al. 2017. J Oral Pathol Med. 46: 991-997. PMID: 28342204
- Prostaglandin E2 Receptor Antagonist with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus. | Ikeh, MAC., et al. 2018. Antimicrob Agents Chemother. 62: PMID: 29263068
- Knockdown of arylalkylamine N-acetyltransferase-like 2 in Drosophila melanogaster. | Anderson, RL., et al. 2019. Arch Insect Biochem Physiol. 102: e21608. PMID: 31385627
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PALDA, 5 mg | sc-203445 | 5 mg | $200.00 | |||
PALDA, 25 mg | sc-203445A | 25 mg | $400.00 |