Molecular structure of PACOCF3, CAS Number: 141022-99-3
PACOCF3 (CAS 141022-99-3)
See product citations (2)
Alternate Names:
Palmityl trifluoromethylketone; PTK
Application:
PACOCF3 is an inhibitor of Ca2+-dependent cytosolic cPLA2
CAS Number:
141022-99-3
Purity:
≥98%
Molecular Weight:
308.42
Molecular Formula:
C17H31F3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PACOCF3 (PTK) is an analog of palmitic acid in which the COOH group is replaced by trifluoromethyl ketone. PACOCF3 is an inhibitor of both Ca2+-dependent cytosolic cPLA2 (IC50=45 muM) and Ca2+-independent group VI iPLA2 (phospholipases A2 iPLA2, IC50=3.8 muM). This compound may act to also alter Ca2+ signaling in renal tubular cells.
PACOCF3 (CAS 141022-99-3) References
- Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. | Jan, CR., et al. 2000. Arch Toxicol. 74: 447-51. PMID: 11097381
- Inhibition of phospholipase A2 activity reduces membrane fluidity in rat hippocampus. | Schaeffer, EL., et al. 2005. J Neural Transm (Vienna). 112: 641-7. PMID: 15830123
- Involvement of cPLA2 inhibition in dexamethasone-induced thymocyte apoptosis. | Cinque, B., et al. 2008. Int J Immunopathol Pharmacol. 21: 539-51. PMID: 18831921
- Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries. | Kauser, K., et al. 1991. Circ Res. 68: 1154-63. PMID: 1901255
- Mechanisms involved in IL-6-induced muscular mechanical hyperalgesia in mice. | Manjavachi, MN., et al. 2010. Pain. 151: 345-355. PMID: 20709454
- Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance. | Han, MS., et al. 2011. J Lipid Res. 52: 1234-1246. PMID: 21447485
- Inhibition of cytosolic Phospholipase A2 prevents prion peptide-induced neuronal damage and co-localisation with Beta III Tubulin. | Last, V., et al. 2012. BMC Neurosci. 13: 106. PMID: 22928663
- Interaction of phospholipase A of the E. coli outer membrane with the inhibitors of eucaryotic phospholipases A₂ and their effect on the Ca²⁺-induced permeabilization of the bacterial membrane. | Belosludtsev, KN., et al. 2014. J Membr Biol. 247: 281-8. PMID: 24477786
- Effects of Phospholipase A2 Inhibitors on Bilayer Lipid Membranes. | Dubinin, MV., et al. 2016. J Membr Biol. 249: 339-47. PMID: 26762382
- Signaling pathways involved in zymosan phagocytosis induced by two secreted phospholipases A2 isolated from Bothrops asper snake venom in macrophages. | Zuliani, JP., et al. 2018. Int J Biol Macromol. 113: 575-582. PMID: 29501751
- The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation. | Kopper, TJ., et al. 2021. Sci Rep. 11: 6341. PMID: 33737707
- Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. | Ackermann, EJ., et al. 1995. J Biol Chem. 270: 445-50. PMID: 7814408
- Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. | Lio, YC., et al. 1996. Biochim Biophys Acta. 1302: 55-60. PMID: 8695655
Inhibitor of:
Enzyme, and group VI iPLA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PACOCF3, 10 mg | sc-201414 | 10 mg | $122.00 | |||
PACOCF3, 50 mg | sc-201414A | 50 mg | $459.00 |