PACE4 Antibody (2D6): sc-517067
- PACE4 Antibody (2D6) is a mouse monoclonal IgG2a κ PACE4 antibody provided at 100 µg/ml
- raised against amino acids 860-969 representing partial length PACE4 of human origin
- recommended for detection of PACE4 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PACE4 Antibody (2D6). This work is in progress.
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PACE4 Antibody (2D6) is a mouse monoclonal IgG2a kappa light chain antibody that detects PACE4 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PACE4 antibody (2D6) is available as a non-conjugated format. PACE4, a member of the subtilisin-like prohormone convertase family, plays a crucial role in processing prohormones and other precursor proteins into active forms, essential for various physiological processes, including hormone regulation and neuropeptide activation. Located primarily in the trans-Golgi network, PACE4 is involved in the secretory pathway, where PACE4 cleaves proproteins to generate biologically active peptides and proteins. This localization ensures efficient substrate access during hormone and neuropeptide maturation and secretion, influencing numerous signaling pathways and biological functions. PACE4 interacts with other proteins in the convertase family, such as furin and PC1/3, underscoring PACE4′s importance in proprotein processing and cellular signaling.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PACE4 Antibody (2D6) References:
- Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells. | Mori, K., et al. 1999. J Biochem. 125: 627-33. PMID: 10050053
- The proprotein convertases furin and PACE4 play a significant role in tumor progression. | Bassi, DE., et al. 2000. Mol Carcinog. 28: 63-9. PMID: 10900462
- The tissue distribution of mRNAs for the PACE4 isoforms, kexin-like processing protease: PACE4C and PACE4D mRNAs are major transcripts among PACE4 isoforms. | Tsuji, A., et al. 1994. Biochem Biophys Res Commun. 202: 1215-21. PMID: 8060295
- PACE4: a subtilisin-like endoprotease prevalent in the anterior pituitary and regulated by thyroid status. | Johnson, RC., et al. 1994. Endocrinology. 135: 1178-85. PMID: 8070361
- Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms. | Tsuji, A., et al. 1994. Biochem Biophys Res Commun. 200: 943-50. PMID: 8179631
- PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE. | Rehemtulla, A., et al. 1993. Biochemistry. 32: 11586-90. PMID: 8218226
- Proprotein processing activity and cleavage site selectivity of the Kex2-like endoprotease PACE4. | Creemers, JW., et al. 1993. FEBS Lett. 336: 65-9. PMID: 8262218
- Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform. | Zhong, M., et al. 1996. FEBS Lett. 396: 31-6. PMID: 8906861
- PACE4: a subtilisin-like endoprotease with unique properties. | Mains, RE., et al. 1997. Biochem J. 321 (Pt 3): 587-93. PMID: 9032441
- A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus. | Mori, K., et al. 1997. J Biochem. 121: 941-8. PMID: 9192737
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PACE4 Antibody (2D6) | sc-517067 | 100 µg/ml | $322.00 |