P7C3 (CAS 301353-96-8)
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P7C3 is a compound of interest in neuroscientific research due to its propensity to bolster neuronal survival. Its mechanism of action is believed to involve the protection of neural cells from cell death, which is a focal point in studies on neurodegeneration. Investigations utilizing P7C3 often investigate into understanding its role in maintaining the integrity of neuronal circuits under conditions that would typically induce cellular stress. This compound also serves as a tool for probing the processes that govern neurogenesis, providing insights into the fundamental biology of brain development and function. Additionally, P7C3 is used in research applications to explore its potential effects on cognitive function, which is related to its neuroprotective properties.
P7C3 (CAS 301353-96-8) References
- P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases. | Pieper, AA., et al. 2014. Chem Soc Rev. 43: 6716-26. PMID: 24514864
- P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury. | Yin, TC., et al. 2014. Cell Rep. 8: 1731-1740. PMID: 25220467
- P7C3 Attenuates the Scopolamine-Induced Memory Impairments in C57BL/6J Mice. | Jiang, B., et al. 2016. Neurochem Res. 41: 1010-9. PMID: 26646000
- P7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo. | Gu, C., et al. 2017. Cell Death Dis. 8: e2858. PMID: 28569794
- P7C3 Suppresses Neuroinflammation and Protects Retinal Ganglion Cells of Rats from Optic Nerve Crush. | Oku, H., et al. 2017. Invest Ophthalmol Vis Sci. 58: 4877-4888. PMID: 28973334
- Neurotherapeutic capacity of P7C3 agents for the treatment of Traumatic Brain Injury. | Blaya, MO., et al. 2019. Neuropharmacology. 145: 268-282. PMID: 30236963
- Neuroprotective efficacy of P7C3 compounds in primate hippocampus. | Bauman, MD., et al. 2018. Transl Psychiatry. 8: 202. PMID: 30258178
- P7C3 Inhibits LPS-Induced Microglial Activation to Protect Dopaminergic Neurons Against Inflammatory Factor-Induced Cell Death in vitro and in vivo. | Gu, C., et al. 2018. Front Cell Neurosci. 12: 400. PMID: 30455635
- Neuroprotective effects of P7C3 against spinal cord injury in rats. | Duan, FX., et al. 2019. Exp Biol Med (Maywood). 244: 1680-1687. PMID: 31718264
- P7C3 attenuates CNS autoimmunity by inhibiting Th17 cell differentiation. | Li, X., et al. 2021. Cell Mol Immunol. 18: 1565-1567. PMID: 32647376
- Antinociceptive effect of intrathecal P7C3 via GABA in a rat model of inflammatory pain. | Ryu, SW., et al. 2021. Eur J Pharmacol. 899: 174029. PMID: 33727053
- The Neurogenic Compound P7C3 Regulates the Aerobic Glycolysis by Targeting Phosphoglycerate Kinase 1 in Glioma. | Chen, W., et al. 2021. Front Oncol. 11: 644492. PMID: 34221965
- Nampt activator P7C3 ameliorates diabetes and improves skeletal muscle function modulating cell metabolism and lipid mediators. | Manickam, R., et al. 2022. J Cachexia Sarcopenia Muscle. 13: 1177-1196. PMID: 35060352
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
P7C3, 10 mg | sc-362776 | 10 mg | $87.00 | |||
P7C3, 50 mg | sc-362776A | 50 mg | $350.00 |