p70 S6 kinase β Antibody (4B11): sc-293269

p70 S6 kinase β Antibody (4B11) is a mouse monoclonal IgG2a kappa light chain antibody that detects p70 S6 kinase β of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). p70 S6 kinase β (4B11) antibody is available in a non-conjugated form, making it suitable for various experimental applications. p70 S6 kinase β plays a crucial role in regulating protein synthesis and cell growth, primarily by phosphorylating ribosomal protein S6, which is essential for translating mRNAs that encode proteins involved in cell cycle progression and metabolism. p70 S6 kinase β is activated in response to growth factors and is part of a signaling cascade that includes the ERK MAP kinase family, which is regulated by upstream kinases such as MEK. Precise regulation of p70 S6 kinase β is vital for maintaining cellular homeostasis and responding to external stimuli, making p70 S6 kinase β a significant target for research in cancer and metabolic disorders. Anti-p70 S6 kinase β antibody (4B11) helps researchers gain insights into signaling pathways that govern cell growth and proliferation, furthering our understanding of various physiological and pathological processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

p70 S6 kinase β Antibody (4B11) References:

1. Cross-talk between the ERK and p70 S6 kinase (S6K) signaling pathways. MEK-dependent activation of S6K2 in cardiomyocytes.  |  Wang, L., et al. 2001. J Biol Chem. 276: 32670-7. PMID: 11431469
2. Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha.  |  Minami, T., et al. 2001. Genes Cells. 6: 1003-15. PMID: 11733037
3. Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily.  |  Kozma, SC., et al. 1990. Proc Natl Acad Sci U S A. 87: 7365-9. PMID: 1699226
4. Identification of mitogen-responsive ribosomal protein S6 kinase pp90rsk, a homolog of Xenopus S6 kinase II, in chicken embryo fibroblasts.  |  Sweet, LJ., et al. 1990. Mol Cell Biol. 10: 2413-7. PMID: 2325657
5. Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase.  |  Alcorta, DA., et al. 1989. Mol Cell Biol. 9: 3850-9. PMID: 2779569
6. S6K2 promises an important therapeutic potential for cancer.  |  Sever, Nİ. and Cengiz Şahin, S. 2019. Future Oncol. 15: 95-102. PMID: 30730779
7. Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer.  |  Sridharan, S. and Basu, A. 2020. Int J Mol Sci. 21: PMID: 32054043
8. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation.  |  Zhao, Y., et al. 1995. Mol Cell Biol. 15: 4353-63. PMID: 7623830
9. Divergent functional roles for p90rsk kinase domains.  |  Bjørbaek, C., et al. 1995. J Biol Chem. 270: 18848-52. PMID: 7642538
10. Human rsk isoforms: cloning and characterization of tissue-specific expression.  |  Moller, DE., et al. 1994. Am J Physiol. 266: C351-9. PMID: 8141249
11. Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.  |  Gout, I., et al. 1998. J Biol Chem. 273: 30061-4. PMID: 9804755
12. Cloning and characterization of RLPK, a novel RSK-related protein kinase.  |  New, L., et al. 1999. J Biol Chem. 274: 1026-32. PMID: 9873047

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p70 S6 kinase β Antibody (4B11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-p70 S6 kinase β Antibody (4B11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p70 S6 kinase β Antibody (4B11) Specifications

Alternate Product Name: p70 S6 kinase β

Product Clone Name: 4B11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-100

Epitope Target: p70 S6 kinase β

Epitope Species: human

Product Reactivity/Detection: p70 S6 kinase β

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for p70 S6 kinase β Antibody (4B11): N/A