p53 Antibody (FL-393): sc-6243
- p53 Antibody (FL-393) is a rabbit polyclonal IgG; 200 µg/ml; or goat IgG; 200 µg/ml, sc-6243-G
- epitope mapping within amino acids 1-393 representing full length p53 of human origin
- Discontinued polyclonal antibody
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p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.
Download thiomersal SDS
Ordering Information
p53 (DO-1): sc-126 [ Recommended monoclonal replacement for p53 (FL-393) ]
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p53 Antibody (DO-1) | sc-126 | 200 µg/ml | $322.00 | |||
p53 Antibody (DO-1): m-IgG Fc BP-HRP Bundle | sc-528099 | 200 µg Ab; 10 µg BP | $361.00 | |||
p53 Antibody (DO-1): m-IgGκ BP-HRP Bundle | sc-520397 | 200 µg Ab, 40 µg BP | $361.00 | |||
p53 Antibody (DO-1): m-IgG2a BP-HRP Bundle | sc-547024 | 200 µg Ab; 10 µg BP | $361.00 | |||
p53 Antibody (DO-1) X | sc-126 X | 200 µg/0.1 ml | $322.00 | |||
p53 Antibody (DO-1) AC | sc-126 AC | 500 µg/ml, 25% agarose | $424.00 | |||
p53 Antibody (DO-1) HRP | sc-126 HRP | 200 µg/ml | $322.00 | |||
p53 Antibody (DO-1) FITC | sc-126 FITC | 200 µg/ml | $336.00 | |||
p53 Antibody (DO-1) PE | sc-126 PE | 200 µg/ml | $349.00 | |||
p53 Antibody (DO-1) Alexa Fluor® 488 | sc-126 AF488 | 200 µg/ml | $364.00 | |||
p53 Antibody (DO-1) Alexa Fluor® 546 | sc-126 AF546 | 200 µg/ml | $364.00 | |||
p53 Antibody (DO-1) Alexa Fluor® 594 | sc-126 AF594 | 200 µg/ml | $364.00 | |||
p53 Antibody (DO-1) Alexa Fluor® 647 | sc-126 AF647 | 200 µg/ml | $364.00 | |||
p53 Antibody (DO-1) Alexa Fluor® 680 | sc-126 AF680 | 200 µg/ml | $364.00 | |||
p53 Antibody (DO-1) Alexa Fluor® 790 | sc-126 AF790 | 200 µg/ml | $364.00 | |||
p53 Antibody (DO-1) B | sc-126 B | 200 µg/ml | $326.00 | |||
p53 Antibody (DO-1) TRITC | sc-126 TRITC | 200 µg/ml | $326.00 | |||
p53 Antibody (DO-1) Alexa Fluor® 405 | sc-126 AF405 | 200 µg/ml | $364.00 |