p38 MAP Kinase Inhibitor VIII CAS: 321351-00-2
MF: C20H16BrClN2O
MW: 415.71
A synthetic inhibitor of p38 MAP kinase.

p38 MAP Kinase Inhibitor VIII (CAS 321351-00-2)

p38 MAP Kinase Inhibitor VIII | CAS 321351-00-2 is rated 5.0 out of 5 by 1.
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Synonym: [4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone
Application: A synthetic inhibitor of p38 MAP kinase
CAS Number: 321351-00-2
Purity: >97%
Molecular Weight: 415.71
Molecular Formula: C20H16BrClN2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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p38 MAP Kinase Inhibitor VIII is a synthetic 4-aminobenzophenone small molecule identified in an optimization study for inhibitors of p38 MAP kinase. p38 MAP Kinase Inhibitor VIII is described to inhibit the p38α and p38β isoforms of the kinase by occupying the ATP-binding cleft. This inhibition is described to potently block the release of TNF-α (IC50 = 5 nM) and the proinflammatory interleukins IL-1β, IL-6, IL-8, and IL-10 (IC50s = 30, 17, 4, 74 nM).


References

1. Ottosen, E.R., et al. 2003. J. Med. Chem. 46: 5651-5662. PMID: 14667219

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (50 mM).
Storage :
Store at 4° C
Melting Point :
219.29° C (Predicted)
Boiling Point :
515.94° C at 760 mmHg (Predicted)
Density :
1.48 g/cm3 (Predicted)
Refractive Index :
n20D 1.69
IC50 :
p38α: IC50 = 40 nM; IL-8: IC50 = 4 nM; TNF-α: IC50 = 5 nM; IL-6: IC50 = 17 nM; IL-1β: IC50 = 30 nM; IL-10: IC50 = 74 nM
pK Values :
pKb: 4.03 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9801969
MDL Number :
MFCD11100188
SMILES :
CC1=CC=CC=C1C(=O)C2=C(C=C(C=C2)NC3=C(C=C(C=C3)Br)N)Cl

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Certificate of Analysis

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Rated 5 out of 5 by from p38 MAP Kinase Inhibitor VIII was reported p38 MAP Kinase Inhibitor VIII was reported as a synthetic inhibitor of p38 MAP kinase used for phosphorylation and desphosphorylation applications, in many articles. -SCBT Publication Review
Date published: 2015-04-12
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