p38 MAP Kinase Inhibitor IX MF: C22H17N7O2
MW: 411.42
A potent ATP-binding pocket-targeting inhibitor against p38α..

p38 MAP Kinase Inhibitor IX

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Synonym: N-(Isoazol-3-yl)-4-methyl-3-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)benzamide
Application: A potent ATP-binding pocket-targeting inhibitor against p38α.
Molecular Weight: 411.42
Molecular Formula: C22H17N7O2
* Refer to Certificate of Analysis for lot specific data (including water content).

p38 MAP Kinase Inhibitor IX is a cell-permeable pyrazolo-pyrimidine compound that acts as a potent ATP-binding pocket-targeting inhibitor against p38α MAP kinase activity. p38 MAP Kinase Inhibitor IX displays little activity against a panel of 21 other commonly studied kinases and 5 CYP 450 isozymes.


References

Das, J., et al. 2008. Bioorg. Med. Chem. Lett. 18, 2652.

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at 4° C
IC50 :
p38α MAP kinase activity : IC50 = 5 nM; 5 CYP 450 isozymes: IC50 = ≥40 µM
Ki Data :
p38α MAP kinase activity : Ki= 0.2 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC3=NC=NC4=C3C=NN4C5=CC=CC=C5

Download SDS (MSDS)

Certificate of Analysis

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