p38 MAP Kinase Inhibitor CAS: 219138-24-6
MF: C20H13ClFN3O
MW: 365.8
A potent p38 MAP kinase inhibitor.

p38 MAP Kinase Inhibitor (CAS 219138-24-6)

p38 MAP Kinase Inhibitor | CAS 219138-24-6 is rated 5.0 out of 5 by 1.
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Synonym: 2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one
Application: A potent p38 MAP kinase inhibitor
CAS Number: 219138-24-6
Purity: >95%
Molecular Weight: 365.8
Molecular Formula: C20H13ClFN3O
* Refer to Certificate of Analysis for lot specific data (including water content).
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p38 MAP Kinase Inhibitor is a potent p38 α (p38 MAP kinase) inhibitor (IC50 = 35 nM).


References

de Laszlo, S.E., et al. 1998. Bioorg. Med. Chem. Lett. 8, 2689.

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml).
Storage :
Store at -20° C
Melting Point :
221.91° C (Predicted)
Boiling Point :
~534.11° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
p38 : IC50 = 35 nM
pK Values :
pKb: 6.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4665
MDL Number :
MFCD03452698
SMILES :
C1=CC(=CC=C1C2=C(NN(C2=O)C3=CC=C(C=C3)Cl)C4=CC=NC=C4)F

Download SDS (MSDS)

Certificate of Analysis

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p38 MAP Kinase Inhibitor  Product Citations

See how others have used p38 MAP Kinase Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 21982708  Sellayah, D. et al. 2011. Cell Metab. 14: 478-90.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Zhao Zhao, L. et al. (PubMed 26299070) used the p38 MAP Kinase Inhibitor to demonstrate that staurosporine induces platelet apoptosis through p38 MAP kinase signaling pathway. -SCBT Publication Review
Date published: 2015-05-27
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