P23 Antibody (JJ12): sc-101497

P23 Antibody (JJ12) is a mouse monoclonal IgG2b antibody that detects P23 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). P23, also known as PTGES3 or TEBP, is a crucial cochaperone that is widely expressed and plays a significant role in signal transduction. P23 is part of the HSP 90-based molecular chaperone complex, where P23 facilitates the disassembly of transcriptional regulatory complexes, thereby influencing receptor-mediated transcriptional activation. P23 is involved in the hormone-dependent chaperoning of estrogen receptor alpha (ERα), which is essential for the maturation of this steroid receptor and the regulation of genes associated with ERα. The localization of P23 in the cytoplasm is vital, as P23 allows for interaction with the glucocorticoid receptor (GR), where P23 is believed to inhibit GR-dependent transcription by disrupting the transcription machinery. P23′s role in various steroid receptor-mediated pathways underscores P23′s importance in cellular signaling and the regulation of diverse biological processes. The upregulation of P23 has been linked to the invasion and metastasis of several cancers, highlighting P23′s potential as a biomarker and therapeutic target in oncology.

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P23 Antibody (JJ12) References:

1. Localization and regional distribution of p23/TMP21 in the brain.  |  Vetrivel, KS., et al. 2008. Neurobiol Dis. 32: 37-49. PMID: 18652896
2. Transgenic overexpression of p23 induces spontaneous hydronephrosis in mice.  |  Lee, J., et al. 2011. Int J Exp Pathol. 92: 251-9. PMID: 21323770
3. p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function.  |  Wang, H., et al. 2011. J Biol Chem. 286: 15821-31. PMID: 21454541
4. Expression, purification and preliminary X-ray crystallographic analysis of Arf1-GDP in complex with dimeric p23 peptide.  |  Zheng, P., et al. 2013. Acta Crystallogr Sect F Struct Biol Cryst Commun. 69: 1155-8. PMID: 24100571
5. The C-terminal region of the human p23 chaperone modulates its structure and function.  |  Seraphim, TV., et al. 2015. Arch Biochem Biophys. 565: 57-67. PMID: 25447839
6. Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer.  |  He, Y., et al. 2016. Nat Commun. 7: 13122. PMID: 27959342
7. p23 protects the human aryl hydrocarbon receptor from degradation via a heat shock protein 90-independent mechanism.  |  Pappas, B., et al. 2018. Biochem Pharmacol. 152: 34-44. PMID: 29555469
8. Lagovirus Non-structural Protein p23: A Putative Viroporin That Interacts With Heat Shock Proteins and Uses a Disulfide Bond for Dimerization.  |  Smertina, E., et al. 2022. Front Microbiol. 13: 923256. PMID: 35923397
9. Interplay of p23 with FKBP51 and their chaperone complex in regulating tau aggregation.  |  Chakraborty, P. and Zweckstetter, M. 2025. Nat Commun. 16: 669. PMID: 39809798
10. p23 protects against ferroptosis of brain microvascular endothelial cells in ischemic stroke.  |  Zhao, Y., et al. 2025. Int J Mol Med. 55: PMID: 39981897

The preferred P23 antibody is P23 Antibody (JJ6): sc-101496.