CDKN2C/p18 INK4c Antibody (18P118): sc-65477

p18 INK4C Antibody (18P118) is a mouse monoclonal IgG2a antibody that detects p18 INK4C in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). p18 INK4C plays a crucial role in regulating the cell cycle by specifically inhibiting cyclin D-Cdk6 kinase activity, which is essential for preventing uncontrolled cell proliferation—a hallmark of cancer. p18 INK4C is primarily located in the nucleus, where p18 INK4C interacts with cyclin-dependent kinases, thereby modulating their activity and ensuring proper cell cycle progression. The gene encoding p18 INK4C is closely related to the p16 INK4A family, and p18 INK4C expression is tightly regulated, particularly in response to growth factors such as TGFβ. Understanding the function and regulation of p18 INK4C is vital, as p18 INK4C dysregulation can contribute to tumorigenesis, making p18 INK4C a significant target for cancer research and therapeutic interventions. With p18 INK4C′s ability to form binary complexes with Cdk4 and Cdk6, p18 INK4C serves as a critical checkpoint in the cell cycle, highlighting p18 INK4C′s importance in maintaining cellular homeostasis and preventing malignancies.

The preferred CDKN2C/p18 INK4c antibody is CDKN2C/p18 INK4c Antibody (118.2): sc-9965.