Date published: 2025-10-17

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p-Tolylacetic acid (CAS 622-47-9)

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Alternate Names:
4-Methylphenylacetic acid
CAS Number:
622-47-9
Molecular Weight:
150.17
Molecular Formula:
CH3C6H4CH2CO2H
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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p-Tolylacetic acid, also known as 4-methylphenylacetic acid, stands as a compelling molecule primarily explored within the realm of organic chemistry and material science research. This compound, characterized by its unique functional groups, plays a pivotal role in the synthesis of various complex molecules and polymers, acting as a precursor or intermediate. Its mechanism of action often involves participating in esterification reactions, where its acetic acid moiety reacts with alcohols under specific conditions to form esters, showcasing its versatility in chemical synthesis. Furthermore, p-Tolylacetic acid′s involvement in catalysis research highlights its potential in facilitating or optimizing chemical reactions, making it a subject of interest for developing more efficient and sustainable chemical processes. The study of this compound extends into the field of materials science, where it contributes to the understanding and development of novel materials with potential applications in technology and industry.


p-Tolylacetic acid (CAS 622-47-9) References

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  2. The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries.  |  Nagasaki, H., et al. 2009. Eur J Pharmacol. 602: 194-202. PMID: 19041642
  3. Total synthesis of (-)-calyciphylline N.  |  Shvartsbart, A. and Smith, AB. 2014. J Am Chem Soc. 136: 870-3. PMID: 24319987
  4. The daphniphyllum alkaloids: total synthesis of (-)-calyciphylline N.  |  Shvartsbart, A. and Smith, AB. 2015. J Am Chem Soc. 137: 3510-9. PMID: 25756504
  5. Indole-3-Acetic Acid Produced by Burkholderia heleia Acts as a Phenylacetic Acid Antagonist to Disrupt Tropolone Biosynthesis in Burkholderia plantarii.  |  Wang, M., et al. 2016. Sci Rep. 6: 22596. PMID: 26935539
  6. Corrigendum: Indole-3-Acetic Acid Produced by Burkholderia heleia Acts as a Phenylacetic Acid Antagonist to Disrupt Tropolone Biosynthesis in Burkholderia plantarii.  |  Wang, M., et al. 2016. Sci Rep. 6: 26217. PMID: 27198175
  7. Application of vinylogous carbamates and vinylogous aminonitriles to the regiospecific synthesis of uniquely functionalized pyrroles and quinolones.  |  Gupton, JT., et al. 2018. Tetrahedron. 74: 7408-7420. PMID: 31289413
  8. Biotransformation of the Fluorinated Nonsteroidal Anti-Inflammatory Pharmaceutical Flurbiprofen in Activated Sludge Results in Accumulation of a Recalcitrant Fluorinated Aromatic Metabolite.  |  Yanaç, K. and Murdoch, RW. 2019. Glob Chall. 3: 1800093. PMID: 31565381
  9. Precise Molecular Design of a Pair of New Regioisomerized Fluorophores With Opposite Fluorescent Properties.  |  Wang, Z., et al. 2021. Front Chem. 9: 823519. PMID: 35127656
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

p-Tolylacetic acid, 5 g

sc-257959
5 g
$22.00

p-Tolylacetic acid, 25 g

sc-257959A
25 g
$66.00