Date published: 2025-9-28

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p-Tolyl isothiocyanate (CAS 622-59-3)

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Alternate Names:
4-Methylphenyl isothiocyanate
CAS Number:
622-59-3
Molecular Weight:
149.21
Molecular Formula:
C8H7NS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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P-Tolyl isothiocyanate (pTIC) is an organic molecule with diverse applications in scientific disciplines. This compound serves as a reagent in the synthesis of various compounds, an enzyme inhibitor, and a tool for protein structure exploration. It has contributed to the development of compounds through its involvement in synthesis processes. Furthermore, P-Tolyl isothiocyanate′s capability to inhibit enzymes stems from its ability to form covalent bonds with the active sites of enzymes, effectively impeding their catalytic activities. In addition, P-Tolyl isothiocyanate functions as a probe to examine protein structures. By selectively binding to specific sites on proteins, it enables the measurement and analysis of protein architecture.


p-Tolyl isothiocyanate (CAS 622-59-3) References

  1. Synthesis of N-(purin-8-yl)arylamines.  |  Swenson, DH., et al. 1993. Chem Res Toxicol. 6: 480-5. PMID: 8374045
  2. Evidence for a radical cage mechanism in the thermal elimination of benzaldoxime thiocarbamates  |  R. F. Hudson and K. A. F. Record . 1976. J. Chem. Soc., Chem. Commun. 539-540.
  3. Insertionsreaktionen von carbonylbis(η-cyclopentadienyl)hydridoniob mit heteroallenen  |  G.E. Herberich ∗, H. Mayer. 1987. Journal of Organometallic Chemistry. 322: C29-C31.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

p-Tolyl isothiocyanate, 5 g

sc-250638
5 g
$48.00