p-Thr Antibody (BDI141): sc-57562
- p-Thr Antibody (BDI141) is a mouse monoclonal IgM, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against phosphothreonine
- recommended for detection of phosphothreonine-containing proteins by WB and IP
- See p-Thr (H-2): sc-5267 for p-Thr antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-Thr Antibody (BDI141). This work is in progress.
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SEE ALSO...
p-Thr Antibody (BDI141) is a mouse monoclonal IgM antibody that detects phosphothreonine in non-species reactive samples through western blotting (WB) and immunoprecipitation (IP). Anti-phosphothreonine antibody (BDI141) specifically recognizes phosphorylated threonine residues, which play a crucial role in regulating various cellular processes, including signal transduction pathways. Phosphothreonine monoclonal antibody (BDI141) enables detection of threonine phosphorylation, which can influence the activity of key proteins involved in cellular signaling, such as ERK and JNK MAP kinases, activated through dual phosphorylation on both tyrosine and threonine residues by MEK family kinases. Understanding threonine phosphorylation dynamics is essential for elucidating mechanisms of cellular communication and response to external stimuli, making phosphothreonine (BDI141) antibody a valuable tool for researchers investigating these critical pathways. Anti-phosphothreonine antibody (BDI141) helps scientists characterize proteins with phosphorylated threonine residues and gain insights into intricate signaling networks that govern cellular behavior.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p-Thr Antibody (BDI141) References:
- Phosphothreonine-212 of Alzheimer abnormally hyperphosphorylated tau is a preferred substrate of protein phosphatase-1. | Rahman, A., et al. 2005. Neurochem Res. 30: 277-87. PMID: 15895832
- Expanded cellular amino acid pools containing phosphoserine, phosphothreonine, and phosphotyrosine. | Steinfeld, JB., et al. 2014. ACS Chem Biol. 9: 1104-12. PMID: 24646179
- Phosphothreonine as a catalytic residue in peptide-mediated asymmetric transfer hydrogenations of 8-aminoquinolines. | Shugrue, CR. and Miller, SJ. 2015. Angew Chem Int Ed Engl. 54: 11173-6. PMID: 26246129
- Prediction of phosphothreonine sites in human proteins by fusing different features. | Zhao, YW., et al. 2016. Sci Rep. 6: 34817. PMID: 27698459
- Biosynthesis and genetic encoding of phosphothreonine through parallel selection and deep sequencing. | Zhang, MS., et al. 2017. Nat Methods. 14: 729-736. PMID: 28553966
- Generating a recombinant phosphothreonine-binding domain for a phosphopeptide of the human transcription factor, c-Myc. | Venegas, LA., et al. 2018. N Biotechnol. 45: 36-44. PMID: 29763736
- Phosphothreonine (pThr)-Based Multifunctional Peptide Catalysis for Asymmetric Baeyer-Villiger Oxidations of Cyclobutanones. | Featherston, AL., et al. 2019. ACS Catal. 9: 242-252. PMID: 31007966
- An Inherent Difference between Serine and Threonine Phosphorylation: Phosphothreonine Strongly Prefers a Highly Ordered, Compact, Cyclic Conformation. | Pandey, AK., et al. 2023. ACS Chem Biol. 18: 1938-1958. PMID: 37595155
- Edwardsiella ictaluri T3SS effector EseN is a phosphothreonine lyase that inactivates ERK1/2, p38, JNK, and PDK1 and modulates cell death in infected macrophages. | Koirala, R., et al. 2023. Microbiol Spectr. 11: e0300323. PMID: 37796003
- Engineered FHA domains can bind to a variety of Phosphothreonine-containing peptides. | Thota, SS., et al. 2024. Protein Eng Des Sel. 37: PMID: 39276365
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Thr Antibody (BDI141) | sc-57562 | 50 µg/0.5 ml | $322.00 |