p-Thr Antibody (1E11): sc-81527
- p-Thr Antibody (1E11) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against a synthetic threonine- phosphorylated peptide
- recommended for detection of phosphothreonine-containing proteins of mouse, rat, human and canine origin by WB and IP
- See p-Thr (H-2): sc-5267 for p-Thr antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-Thr Antibody (1E11). This work is in progress.
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SEE ALSO...
p-Thr Antibody (1E11) is a mouse monoclonal IgG1 antibody that detects phosphothreonine in mouse, rat, human, and canine samples through applications such as western blotting (WB) and immunoprecipitation (IP). p-Thr monoclonal antibody (1E11) specifically recognizes phosphorylated threonine residues, which are critical for regulating various cellular processes, including signal transduction pathways. The phosphorylation of threonine residues plays a significant role in activating key mitogen-activated protein kinases (MAPKs) such as ERK and JNK, which mediate cellular responses to growth factors and stress signals. p-Thr (1E11) antibody enables researchers to investigate threonine phosphorylation dynamics and implications in cellular signaling, providing insights into mechanisms underlying various physiological and pathological conditions. p-Thr (1E11) monoclonal antibody serves as an invaluable tool for studying protein interaction networks and modifications that govern cellular behavior, advancing our understanding of cellular signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p-Thr Antibody (1E11) References:
- p13(SUC1) and the WW domain of PIN1 bind to the same phosphothreonine-proline epitope. | Landrieu, I., et al. 2001. J Biol Chem. 276: 1434-8. PMID: 11013245
- Identification of O-phosphoserine, O-phosphothreonine and gamma-carboxyglutamic acid in the non-collagenous proteins of bovine cementum; comparison with dentin, enamel and bone. | Glimcher, MJ., et al. 1979. Calcif Tissue Int. 28: 83-6. PMID: 115557
- Catalytic subunit of protein kinase A caged at the activating phosphothreonine. | Zou, K., et al. 2002. J Am Chem Soc. 124: 8220-9. PMID: 12105899
- FHA domains as phospho-threonine binding modules in cell signaling. | Hammet, A., et al. 2003. IUBMB Life. 55: 23-7. PMID: 12716058
- AMBER force-field parameters for phosphorylated amino acids in different protonation states: phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine. | Homeyer, N., et al. 2006. J Mol Model. 12: 281-9. PMID: 16240095
- Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase. | Zhu, Y., et al. 2007. Mol Cell. 28: 899-913. PMID: 18060821
- Salmonella type III effector SpvC, a phosphothreonine lyase, contributes to reduction in inflammatory response during intestinal phase of infection. | Haneda, T., et al. 2012. Cell Microbiol. 14: 485-99. PMID: 22188134
- Synthesis of phosphopeptides containing O-phosphoserine or O-phosphothreonine. | Arendt, A., et al. 1989. Int J Pept Protein Res. 33: 468-76. PMID: 2506143
- Simultaneous formation of peptides and nucleotides from N-phosphothreonine. | Zhou, W., et al. 1996. Orig Life Evol Biosph. 26: 547-60. PMID: 9008881
- Decomposition of phosphoserine and phosphothreonine during acid hydrolysis. | Bylund, DB. and Huang, TS. 1976. Anal Biochem. 73: 477-85. PMID: 962058
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Thr Antibody (1E11) | sc-81527 | 50 µg/0.5 ml | $322.00 |