p-Ser/Phosphoserine Antibody (1C8): sc-81515
- p-Ser/Phosphoserine Antibody (1C8) is a mouse monoclonal IgM, cited in 7 publications, provided at 50 µg/0.5 ml
- raised against phosphoserine
- recommended for detection of a broad range of serine-phosphorylated proteins in crude cell extracts, preferring positively charged amino acids directly neighbored to phosphoserine of mouse, rat, human and canine origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-Ser/Phosphoserine Antibody (1C8). This work is in progress.
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p-Ser Antibody (1C8) is a mouse monoclonal IgM antibody that detects phosphoserine in mouse, rat, human, and canine samples through applications such as western blotting (WB) and immunoprecipitation (IP). p-Ser (1C8) antibody plays a crucial role in studying the phosphorylation of serine residues, a key post-translational modification that significantly influences protein function and cellular signaling pathways. Phosphorylation of serine residues can induce conformational changes in proteins, which may enhance or inhibit their enzymatic activity and alter their interactions with other proteins. This dynamic modification is essential for regulating various cellular processes, including cell growth, differentiation, and apoptosis. Anti-p-Ser antibody (1C8) enables researchers to effectively characterize proteins with phosphorylated serine residues, providing insights into the intricate networks of cellular signaling and the physiological implications of serine phosphorylation in health and disease.
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p-Ser/Phosphoserine Antibody (1C8) References:
- Biosynthesis of phosphoserine in the Methanococcales. | Helgadóttir, S., et al. 2007. J Bacteriol. 189: 575-82. PMID: 17071763
- Possible roles of L-phosphoserine in the pathogenesis of Alzheimer's disease. | Klunk, WE., et al. 1991. Mol Chem Neuropathol. 15: 51-73. PMID: 1837714
- Phosphoserine promotes osteogenic differentiation of human adipose stromal cells through bone morphogenetic protein signalling. | Ying, X., et al. 2014. Cell Biol Int. 38: 309-17. PMID: 24155130
- Phosphoserine inhibits neighboring arginine methylation in the RKS motif of histone H3. | Leal, JA., et al. 2021. Arch Biochem Biophys. 698: 108716. PMID: 33309545
- A multi-purpose, regenerable, proteome-scale, human phosphoserine resource for phosphoproteomics. | Gassaway, BM., et al. 2022. Nat Methods. 19: 1371-1375. PMID: 36280721
- Customized synthesis of phosphoprotein bearing phosphoserine or its nonhydrolyzable analog. | Liu, D., et al. 2023. Synth Syst Biotechnol. 8: 69-78. PMID: 36514487
- The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators. | Appel, LM., et al. 2023. Nat Commun. 14: 166. PMID: 36631525
- Novel adhesive mineral-organic bone cements based on phosphoserine and magnesium phosphates or oxides. | Renner, T., et al. 2023. J Mater Sci Mater Med. 34: 14. PMID: 36964421
- Phosphoserine enhanced Cu-doped bioactive glass dynamic dual-network hydrogel for craniofacial bone defect repair. | Liu, Y., et al. 2023. Regen Biomater. 10: rbad054. PMID: 37287897
- Phosphoserine aminotransferase deficiency diagnosed by whole-exome sequencing and LC-MS/MS reanalysis: A case report and review of literature. | Li, J., et al. 2024. Mol Genet Genomic Med. 12: e2400. PMID: 38546032
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Ser/Phosphoserine Antibody (1C8) | sc-81515 | 50 µg/0.5 ml | $322.00 |