p-PYK2 Antibody (14F6): sc-81512

p-PYK2 Antibody (14F6) is a mouse monoclonal IgG1 antibody that detects p-PYK2 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). p-PYK2, also known as proline-rich tyrosine kinase 2, plays a crucial role in cellular signaling pathways, particularly in the central nervous system where p-PYK2 is highly expressed. p-PYK2 is rapidly phosphorylated on specific tyrosine residues in response to various stimuli, which is essential for the activation of downstream signaling cascades, including the MAPK pathway. Notably, p-PYK2 is phosphorylated at Tyr 402 following stimulation with heregulin, leading to the formation of a multiprotein complex that facilitates the phosphorylation of p190 RhoGAP by Src, thereby influencing cellular processes such as ion channel modulation and cell migration. Additionally, p-PYK2 contains multiple phosphorylation sites, including those within the activation loop at Tyr 579 and Tyr 580, as well as a potential Grb2-binding site at Tyr 881, which are critical for regulatory functions. p-PYK2 Antibody (14F6) serves as an invaluable tool for researchers studying the intricate signaling mechanisms involving PYK2 and its role in various physiological and pathological processes.

The preferred p-PYK2 antibody is p-PYK2 Antibody (13.Tyr 402): sc-293142.