p-PP2A-C alpha / beta Antibody (4B10): sc-81602
- p-PP2A-Cα/β Antibody (4B10) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against C-terminal amino acids Tyr 307 phosphorylated at Tyr 307 of PP2A-C of human origin
- recommended for detection of phosphorylated PP2A-C α and β isoforms of human origin by ELISA
- See p-PP2A-Cα/β (F-8): sc-271903 for p-PP2A-Cα/β antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for p-PP2A-Cα/β Antibody (4B10). These reagents are now offered in bundles with p-PP2A-Cα/β Antibody (4B10) (see ordering information below).
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p-PP2A-Cα/β Antibody (4B10) is a mouse monoclonal IgG1 antibody that detects p-PP2A-Cα/β in human samples through applications such as enzyme-linked immunosorbent assay (ELISA). p-PP2A-Cα/β plays a crucial role in the regulation of various cellular processes, including cell division, apoptosis, and signal transduction, primarily through its function as a serine/threonine phosphatase. The phosphorylation state of p-PP2A-Cα/β is vital for activity and regulation, as phosphorylation can modulate enzyme interaction with various substrates and regulatory proteins, thereby influencing downstream signaling pathways. This regulation is particularly important in maintaining cellular homeostasis and preventing uncontrolled cell growth, which can lead to cancer. anti-p-PP2A-Cα/β antibody (4B10) provides reliable detection and quantification of this phosphorylated protein, facilitating research into its role in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p-PP2A-C alpha / beta Antibody (4B10) References:
- Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. | Liu, R., et al. 2008. J Cell Mol Med. 12: 241-57. PMID: 18208556
- B56-PP2A regulates motor dynamics for mitotic chromosome alignment. | Xu, P., et al. 2014. J Cell Sci. 127: 4567-73. PMID: 25179604
- Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression. | Liu, Y., et al. 2017. Sci Rep. 7: 1630. PMID: 28487562
- Peroxiredoxin II negatively regulates BMP2-induced osteoblast differentiation and bone formation via PP2A Cα-mediated Smad1/5/9 dephosphorylation. | Kim, KM., et al. 2019. Exp Mol Med. 51: 1-11. PMID: 31160554
- PP2AC Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu309 Methylation. | Frohner, IE., et al. 2020. Cell Rep. 30: 3171-3182.e6. PMID: 32130916
- RNA helicase DDX5 suppresses IFN-I antiviral innate immune response by interacting with PP2A-Cβ to deactivate IRF3. | Zan, J., et al. 2020. Exp Cell Res. 396: 112332. PMID: 33065113
- NXNL1 negatively regulates osteoblast differentiation via GDF15-induced PP2A Cα dependent manner in MC3T3-E1 cells. | Kim, KM. and Jang, WG. 2022. Biofactors. 48: 239-248. PMID: 34932831
- Mitochondria-targeted catalase induced cell malignant transformation by the downregulation of p53 protein stability via USP28/miR-200b/PP2A-Cα axis. | Wen, C., et al. 2024. Arch Biochem Biophys. 758: 110047. PMID: 38844154
- The PP2A regulator IER5L supports prostate cancer progression. | Crespo, JR., et al. 2024. Cell Death Dis. 15: 514. PMID: 39025841
- HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma. | Turnham, RE., et al. 2024. Cancer Res.. PMID: 39652575
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-PP2A-Cα/β Antibody (4B10) | sc-81602 | 200 µg/ml | $322.00 | |||
p-PP2A-Cα/β Antibody (4B10): m-IgG Fc BP-HRP Bundle | sc-539642 | 200 µg Ab; 10 µg BP | $361.00 | |||
p-PP2A-Cα/β Antibody (4B10): m-IgG1 BP-HRP Bundle | sc-541625 | 200 µg Ab; 20 µg BP | $361.00 |