p-RELA/NFκB p65 Antibody (A-8): sc-166748

p-NFκB p65 Antibody (A-8) is a mouse monoclonal IgM antibody that detects p-NFκB p65 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). p-NFκB p65 monoclonal antibody (A-8) is available in a non-conjugated form, specifically targeting the phosphorylated Ser 311 residue of NFκB p65. NFκB p65 plays a crucial role in regulating immune responses, cell proliferation, and survival, making NFκB p65 a key player in various physiological and pathological processes, including inflammation and cancer. Located primarily in the cytoplasm under resting conditions, NFκB p65 translocates to the nucleus upon activation by various stimuli, such as cytokines and growth factors, where NFκB p65 binds to specific DNA sequences to initiate transcription of target genes. This translocation is vital for the timely expression of genes involved in immune and inflammatory responses, highlighting NFκB p65′s role in maintaining cellular homeostasis and responding to stress signals. The phosphorylation of NFκB p65 at Serine-311, mediated by protein kinase C ζ, enhances transcriptional activity, further underscoring the significance of post-translational modifications in regulating this transcription factor. anti-p-NFκB p65 antibody (A-8) is an essential tool for studying the phosphorylation of NFκB p65 at Serine-311, shedding light on its role in transcriptional regulation and cellular signaling pathways.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-RELA/NFκB p65 Antibody (A-8) has 80 citations in a variety of scientific publications.

Primary antibodies like Anti-p-RELA/NFκB p65 Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-RELA/NFκB p65 Antibody (A-8) Specifications

Alternate Product Name: RELA, RelA, p65, NFKB3

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: Ser 311

Epitope Target: NFκB p65

Epitope Species: human

Product Reactivity/Detection: Ser 311 phosphorylated NFκB p65

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 80 citations in various scientific publications

Available Conjugates/Forms for p-RELA/NFκB p65 Antibody (A-8): P: Blocking Peptide

The preferred RELA/NFκB p65 antibody is RELA/NFκB p65 Antibody (F-6): sc-8008.