p-JNK Antibody (9H8): sc-81502
- p-JNK Antibody (9H8) is a mouse monoclonal IgG1, cited in 38 publications, provided at 50 µg/0.5 ml
- raised against phosphopeptide corresponding to amino acid residues surrounding the pThr-Gly/Pro-pTyr motif of JNK of human origin
- recommended for detection of both Tyr 185 phosphorylated JNK1, JNK2 and JNK3 and Thr 183 and Tyr 185 dually phosphorylated JNK1, JNK2 and JNK3 of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with the non-phosphorylated form of JNK
- See p-JNK (G-7): sc-6254 for p-JNK antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-JNK Antibody (9H8). This work is in progress.
p-JNK Antibody (9H8) is a mouse monoclonal IgG1 antibody raised against phosphorylated human c-Jun N-terminal kinase (JNK), a crucial stress-activated protein kinase. p-JNK mouse monoclonal antibody (9H8) recognizes JNK only when phosphorylated and demonstrates broad species cross-reactivity, detecting p-JNK in mouse, rat, and human samples through Western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) applications. The JNK family, which includes three members, JNK1, JNK2, and JNK3, undergoes activation through a sophisticated dual phosphorylation mechanism at specific threonine and tyrosine residues. This phosphorylation proves essential for JNK′s function in mediating cellular responses to stress, inflammation, and apoptotic signals. Among JNK′s key substrates, c-Jun stands out as a critical transcription factor that, when phosphorylated by JNK, regulates gene expression patterns in response to various stress signals. Through this phosphorylation cascade, JNK exerts significant influence over cell survival and proliferation decisions. The importance of JNK signaling becomes particularly evident in various pathological conditions, including cancer progression and neurodegenerative diseases, where altered JNK activity can contribute to disease development. Through these diverse cellular roles, p-JNK (9H8) antibody provides researchers with a valuable tool for investigating the complex signaling networks that control cellular responses to environmental challenges and stress conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p-JNK Antibody (9H8) References:
- Protein kinase p-JNK is correlated with the activation of AP-1 and its associated Jun family proteins in hepatocellular carcinoma. | Guo, L., et al. 2005. Life Sci. 77: 1869-78. PMID: 15927205
- LS8 cell apoptosis induced by NaF through p-ERK and p-JNK - a mechanism study of dental fluorosis. | Zhao, L., et al. 2016. Acta Odontol Scand. 74: 539-549. PMID: 27624793
- Ambroxol attenuates cisplatin-induced hepatotoxicity and nephrotoxicity via inhibition of p-JNK/p-ERK. | Bishr, A., et al. 2019. Can J Physiol Pharmacol. 97: 55-64. PMID: 30383980
- Inhibition of p-mTOR represses PS1 transcription by reducing p-JNK. | Das, HK. and Hontiveros, SS. 2020. Front Biosci (Landmark Ed). 25: 1297-1304. PMID: 32114433
- CAB39 Promotes the Proliferation of Nasopharyngeal Carcinoma CNE-1 Cells via Up-Regulating p-JNK. | Peng, L., et al. 2020. Cancer Manag Res. 12: 11203-11209. PMID: 33177871
- Anti-Inflammatory Dipeptide, a Metabolite from Ambioba Secretion, Protects Cerebral Ischemia Injury by Blocking Apoptosis Via p-JNK/Bax Pathway. | Zhang, Q., et al. 2021. Front Pharmacol. 12: 689007. PMID: 34220513
- [Effects of electroacupuncture on neurological function and expressions of p-JNK and Beclin-1 in traumatic brain injury rats]. | Liu, RC., et al. 2023. Zhen Ci Yan Jiu. 48: 475-80. PMID: 37247861
- Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death. | Win, S., et al. 2024. Front Cell Dev Biol. 12: 1359152. PMID: 38559813
- Correction: RacGAP1 promotes the malignant progression of cervical cancer by regulating AP-1 via miR-192 and p-JNK. | Zhang, T., et al. 2024. Cell Death Dis. 15: 528. PMID: 39048575
- Vitamin B6 Via p-JNK/Nrf-2/NF-κB Signaling Ameliorates Cadmium Chloride-Induced Oxidative Stress Mediated Memory Deficits in Mice Hippocampus. | Nasir, A., et al. 2024. Curr Neuropharmacol.. PMID: 39092643
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-JNK Antibody (9H8) | sc-81502 | 50 µg/0.5 ml | $322.00 |