p-Integrin β3/ITGB3/CD61 Antibody (pY759.7A): sc-136458

p-Integrin β3 Antibody (pY759.7A) is a mouse monoclonal IgG1 kappa light chain antibody that detects phosphorylated Integrin β3 specifically at Tyr 759 in human samples and Tyr 758 in mouse and rat samples by western blotting (WB) and immunoprecipitation (IP). anti-Integrin β3 antibody (pY759.7A) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. Integrin β3 plays a crucial role in cell adhesion and signaling, functioning as a key mediator in the interaction between cells and the extracellular matrix. Integrin β3 is primarily located on the cell surface, where Integrin β3 forms heterodimers with α subunits, allowing binding to ligands essential for cellular processes such as migration, proliferation, and survival. The structural integrity of Integrin β3 enables signal transduction from the extracellular environment into the cell, influencing various biological responses. Notably, phosphorylation of specific tyrosine residues, such as Tyr 759, is critical for recruiting signaling proteins like GRB2 and SHC, which further underscores the importance of post-translational modifications in regulating Integrin β3′s function. anti-Integrin β3 antibody (pY759.7A) serves as an invaluable tool for researchers investigating the complex signaling pathways that govern cell behavior in health and disease.

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p-Integrin β3/ITGB3/CD61 Antibody (pY759.7A) References:

1. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
2. Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation.  |  Bledzka, K., et al. 2010. J Biol Chem. 285: 30370-4. PMID: 20702409
3. Tyrosine phosphorylation as a conformational switch: a case study of integrin β3 cytoplasmic tail.  |  Deshmukh, L., et al. 2011. J Biol Chem. 286: 40943-53. PMID: 21956114
4. Puerarin specifically disrupts osteoclast activation via blocking integrin-β3 Pyk2/Src/Cbl signaling pathway.  |  Qiu, Z., et al. 2022. J Orthop Translat. 33: 55-69. PMID: 35228997
5. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
6. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
7. Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation.  |  Law, DA., et al. 1996. J Biol Chem. 271: 10811-5. PMID: 8631894
8. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
9. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069
10. Requirement of integrin beta3 tyrosine 747 for beta3 tyrosine phosphorylation and regulation of alphavbeta3 avidity.  |  Blystone, SD., et al. 1997. J Biol Chem. 272: 28757-61. PMID: 9353346

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-Integrin β3/ITGB3/CD61 Antibody (pY759.7A) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-p-Integrin β3/ITGB3/CD61 Antibody (pY759.7A) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-Integrin β3/ITGB3/CD61 Antibody (pY759.7A) Specifications

Alternate Product Name: Integrin β3

Product Clone Name: pY759.7A

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: Tyr 759

Epitope Target: Integrin β3

Epitope Species: human

Product Reactivity/Detection: Tyr 759 phosphorylated Integrin β3 of human origin and correspondingly Tyr 758 phosphorylated Integrin β3 of mouse and rat origin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for p-Integrin β3/ITGB3/CD61 Antibody (pY759.7A): AC: Agarose, HRP: Horseradish Peroxidase

The preferred Integrin αV/β3/CD51/CD61 antibody is Integrin αV/β3/CD51/CD61 Antibody (23C6): sc-7312.