Date published: 2026-4-24

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p-Fluoro-DL-phenylalanine (CAS 51-65-0)

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Alternate Names:
4-Fluorophenylalanine
CAS Number:
51-65-0
Molecular Weight:
183.18
Molecular Formula:
C9H10FNO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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p-Fluoro-DL-phenylalanine is a synthetic amino acid that is an analog of phenylalanine, an amino acid present in proteins. The addition of a fluorine atom significantly alters its properties and interactions within biological systems. The fluorine atom is highly electronegative, making the p-fluoro substitution influential in terms of the molecule′s electronic distribution, chemical reactivity, and ability to engage in hydrogen bonding. These changes can affect how the modified amino acid interacts with enzymes, receptors, and other proteins, which may be useful for studying various biochemical pathways and processes. In chemical synthesis, the presence of both D- and L- forms in the racemic mixture of p-fluoro-DL-phenylalanine offers an opportunity to explore the effects of chirality on biological activity and chemical reactivity.


p-Fluoro-DL-phenylalanine (CAS 51-65-0) References

  1. (De)regulation of key enzyme steps in the shikimate pathway and phenylalanine-specific pathway of the actinomycete Amycolatopsis methanolica.  |  Kloosterman, H., et al. 2003. Microbiology (Reading). 149: 3321-3330. PMID: 14600244
  2. Comparison of two alternative dominant selectable markers for wine yeast transformation.  |  Cebollero, E. and Gonzalez, R. 2004. Appl Environ Microbiol. 70: 7018-23. PMID: 15574895
  3. Studies on the inhibition of Moloney murine leukemia virus reverse transcriptase by N-tritylamino acids and N-tritylamino acid-nucleotide compounds.  |  Hawtrey, A., et al. 2008. Nucleosides Nucleotides Nucleic Acids. 27: 1011-23. PMID: 18711664
  4. L-tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes.  |  Gaines, CG., et al. 1982. Planta. 156: 233-40. PMID: 24272471
  5. Obtainment, selection and characterization of a mutant strain of Kluyveromyces marxianus that displays improved production of 2-phenylethanol and enhanced DAHP synthase activity.  |  de Lima, LA., et al. 2021. J Appl Microbiol. 130: 878-890. PMID: 32706912
  6. Structure-activity relationships among substituted N-benzoyl derivatives of phenylalanine and its analogues in a microbial antitumor prescreen III: derivatives of p-fluoro-DL-phenylalanine.  |  Otani, TT. and Briley, MR. 1985. J Pharm Sci. 74: 40-3. PMID: 3920381
  7. Oxidation and oxygenation of L-amino acids catalyzed by a L-phenylalanine oxidase (deaminating and decarboxylating) from Pseudomonas sp. P-501.  |  Koyama, H. 1984. J Biochem. 96: 421-7. PMID: 6501250

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

p-Fluoro-DL-phenylalanine, 5 g

sc-255406
5 g
$94.00

p-Fluoro-DL-phenylalanine, 25 g

sc-255406A
25 g
$240.00