p-ErbB4/HER4 Antibody (4C6): sc-81491
- p-ErbB4/HER4 Antibody (4C6) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against phosphopeptide corresponding to amino acid residues surrounding tyrosine 1242 of ErbB-4 of human origin
- recommended for detection of Tyr 1242 phosphorylated ErbB-4 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-ErbB4/HER4 Antibody (4C6). This work is in progress.
p-ErbB-4 Antibody (4C6) is a mouse monoclonal IgG1 antibody that detects ErbB-4 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. anti-p-ErbB-4 antibody (4C6) specifically recognizes the phosphorylated form of ErbB-4, a member of the epidermal growth factor receptor family, which plays a crucial role in cell signaling pathways that regulate cell proliferation and differentiation. ErbB-4 is primarily located on the cell membrane, where forming homodimers or heterodimers with other members of the receptor family upon ligand binding leads to the activation of downstream signaling cascades. This localization allows ErbB-4 to interact with various ligands, including heregulin, which promotes proteolytic cleavage and ectodomain release. These fragments can then engage in autocrine or paracrine signaling, influencing cellular responses in tissues such as breast carcinoma, skeletal muscle, heart, pituitary, brain, and cerebellum. Post-translational modifications of ErbB-4, particularly tyrosine phosphorylation, enhance catalytic activity and are essential for mediating cellular responses to growth factors, making p-ErbB-4 (4C6) monoclonal antibody a valuable tool for studying receptor dynamics in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p-ErbB4/HER4 Antibody (4C6) References:
- Heregulin-dependent trafficking and cleavage of ErbB-4. | Zhou, W. and Carpenter, G. 2000. J Biol Chem. 275: 34737-43. PMID: 10944525
- The basic biology of HER2. | Rubin, I. and Yarden, Y. 2001. Ann Oncol. 12 Suppl 1: S3-8. PMID: 11521719
- Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment. | Arasada, RR. and Carpenter, G. 2005. J Biol Chem. 280: 30783-7. PMID: 15985438
- Localization of the human HER4/erbB-4 gene to chromosome 2. | Zimonjic, DB., et al. 1995. Oncogene. 10: 1235-7. PMID: 7700649
- Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. | Plowman, GD., et al. 1993. Proc Natl Acad Sci U S A. 90: 1746-50. PMID: 8383326
- An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4. | Chen, X., et al. 1996. J Biol Chem. 271: 7620-9. PMID: 8631797
- Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation. | Vecchi, M., et al. 1996. J Biol Chem. 271: 18989-95. PMID: 8702564
- Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4. | Komurasaki, T., et al. 1997. Oncogene. 15: 2841-8. PMID: 9419975
- Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin. | Vecchi, M., et al. 1998. J Biol Chem. 273: 20589-95. PMID: 9685416
- Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types. | Srinivasan, R., et al. 1998. J Pathol. 185: 236-45. PMID: 9771476
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-ErbB4/HER4 Antibody (4C6) | sc-81491 | 50 µg/0.5 ml | $322.00 |