p-Cdk5 Antibody (C-7): sc-377558

p-Cdk5 Antibody (C-7) is a mouse monoclonal IgG3 kappa light chain antibody that detects Ser 159 phosphorylated Cdk5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p-Cdk5 (C-7) antibody is available in a non-conjugated form, providing researchers with a versatile tool for studying this critical protein. Cyclin-dependent kinase 5 (Cdk5) plays a vital role in neuronal function, as Cdk5 is predominantly active in neuronal cells and is essential for processes such as neuronal migration, synaptic plasticity, and neurotransmitter release regulation. Cdk5 (C-7) monoclonal antibody recognizes a unique structure among cyclin-dependent kinases, as Cdk5 does not require cyclin binding for activation but instead relies on p35 binding and specific phosphorylation events. The interaction between Cdk5 and p35 is crucial for kinase activity, and phosphorylation at serine 159 is a key regulatory mechanism that enhances activity. Understanding Cdk5 structural dynamics and activation mechanisms is essential for elucidating Cdk5′s role in neurodegenerative diseases and other neurological disorders, making anti-p-Cdk5 antibody (C-7) an invaluable asset for researchers in the field.

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p-Cdk5 Antibody (C-7) References:

1. Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation.  |  Sharma, P., et al. 1999. Proc Natl Acad Sci U S A. 96: 11156-60. PMID: 10500146
2. Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.  |  Zukerberg, LR., et al. 2000. Neuron. 26: 633-46. PMID: 10896159
3. Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression.  |  Hellmich, MR., et al. 1992. Proc Natl Acad Sci U S A. 89: 10867-71. PMID: 1279696
4. CDK5: Key Regulator of Apoptosis and Cell Survival.  |  Roufayel, R. and Murshid, N. 2019. Biomedicines. 7: PMID: 31698798
5. CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation.  |  Chu, Q., et al. 2021. Cancer Med. 10: 3689-3699. PMID: 33960694
6. The role of Cdk5 in neurological disorders.  |  Ao, C., et al. 2022. Front Cell Neurosci. 16: 951202. PMID: 35966199
7. CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth.  |  Yin, S., et al. 2023. Cell Rep. 42: 112316. PMID: 36995937
8. Regulation of NLGN3 and the Synaptic Rho-GEF Signaling Pathway by CDK5.  |  Jeong, J., et al. 2023. J Neurosci. 43: 7264-7275. PMID: 37699715
9. A brain-specific activator of cyclin-dependent kinase 5.  |  Lew, J., et al. 1994. Nature. 371: 423-6. PMID: 8090222
10. cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization.  |  Shetty, KT., et al. 1993. Proc Natl Acad Sci U S A. 90: 6844-8. PMID: 8341707

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-Cdk5 Antibody (C-7) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-p-Cdk5 Antibody (C-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-Cdk5 Antibody (C-7) Specifications

Alternate Product Name: Cdk5

Product Clone Name: C-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: Ser 159

Epitope Target: Cdk5

Epitope Species: human

Product Reactivity/Detection: Ser 159 phosphorylated Cdk5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for p-Cdk5 Antibody (C-7): P: Blocking Peptide

The preferred Cdk5 antibody is Cdk5 Antibody (J-3): sc-6247.