p-Src Antibody (pY530.31): sc-136012
- p-Src Antibody (pY530.31) is a mouse monoclonal IgG2b provided at 50 µg/0.5 ml
- raised against a short amino acid sequence containing phosphorylated Tyr 528 of Fyn of human origin
- recommended for detection of Tyr 530 phosphorylated c-Src of human origin, Tyr 535 phosphorylated c-Src of mouse origin, and Tyr 528 phosphorylated Fyn of human and mouse origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-Src Antibody (pY530.31). This work is in progress.
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SEE ALSO...
p-c-Src Antibody (pY530.31) is a mouse monoclonal IgG2b antibody raised against the tyrosine 530 phosphorylation site of human c-Src, a crucial regulatory site for this non-receptor tyrosine kinase. p-c-Src mouse monoclonal antibody (pY530.31) specifically recognizes c-Src only when phosphorylated at tyrosine 530 and demonstrates broad species cross-reactivity, detecting phosphorylated c-Src in mouse, rat, and human samples through Western blotting (WB) and immunoprecipitation (IP) applications. This phosphorylation site holds particular significance in c-Src regulation, as phosphorylation at tyrosine 530 acts as a molecular brake, maintaining c-Src in an inactive conformation to prevent inappropriate signaling. c-Src primarily resides in the cytoplasm and associates with the inner surface of the plasma membrane, where c-Src participates in signal transduction pathways controlling cellular processes such as proliferation, differentiation, and motility. The precise regulation of c-Src through tyrosine 530 phosphorylation proves especially critical in tissues with high c-Src expression, such as neuronal tissues and platelets, where maintaining proper cellular homeostasis depends on preventing aberrant c-Src activation that could lead to uncontrolled cell growth and oncogenesis. Anti-p-c-Src monoclonal antibody (pY530.31) serves as a valuable tool for researchers investigating c-Src′s activation state and its role in various signaling pathways, providing crucial insights into both normal physiological functions and disease mechanisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Src Antibody (pY530.31) | sc-136012 | 50 µg/0.5 ml | $322.00 |