p-Bcl10 Antibody (6D3): sc-81484

p-Bcl10 Antibody (6D3) is a mouse monoclonal IgG1 antibody that detects Ser 138 phosphorylated Bcl10 of mouse origin by western blotting (WB) and immunoprecipitation (IP). anti-p-Bcl10 antibody (6D3) is available as the non-conjugated form. Bcl10, also known as CIPER, c-CARMEN, and mE10, plays a crucial role in the regulation of apoptosis and immune responses, making Bcl10 an important protein in the study of various lymphomas and other tumor types. Bcl10 is primarily located in the cytoplasm, where Bcl10 interacts with other signaling molecules to activate the NFκB pathway, a key regulator of immune and inflammatory responses. Cytoplasmic localization of Bcl10 allows for rapid signaling in response to cellular stimuli, facilitating the transduction of signals that lead to cell survival or apoptosis. Notably, Bcl10 contains an N-terminal caspase recruitment domain (CARD), which is essential for NFκB activation and apoptosis induction. While Bcl10 has been implicated in the pathogenesis of MALT B cell lymphomas, studies have shown that Bcl10 is not mutated in many human tumors, highlighting a complex role in cancer biology. p-Bcl10 (6D3) monoclonal antibody′s specific detection of phosphorylated Bcl10 makes this antibody a valuable tool for researchers investigating molecular mechanisms underlying Bcl10′s function and implications in disease.

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p-Bcl10 Antibody (6D3) References:

1. BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma.  |  Ye, H., et al. 2000. Am J Pathol. 157: 1147-54. PMID: 11021819
2. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure.  |  Ruland, J., et al. 2001. Cell. 104: 33-42. PMID: 11163238
3. Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway.  |  Lucas, PC., et al. 2001. J Biol Chem. 276: 19012-9. PMID: 11262391
4. Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling.  |  Yui, D., et al. 2001. Oncogene. 20: 4317-23. PMID: 11466612
5. Bcl10.  |  Thome, M. and Tschopp, J. 2002. Curr Biol. 12: R45. PMID: 11818074
6. Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.  |  Zhou, H., et al. 2004. Nature. 427: 167-71. PMID: 14695475
7. New roles for Bcl10 in B-cell development and LPS response.  |  Fischer, KD., et al. 2004. Trends Immunol. 25: 113-6. PMID: 15049289
8. Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling.  |  Scharschmidt, E., et al. 2004. Mol Cell Biol. 24: 3860-73. PMID: 15082780
9. BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2.  |  Liu, Y., et al. 2004. J Biol Chem. 279: 37436-44. PMID: 15213237
10. MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression.  |  Ye, H., et al. 2005. J Pathol. 205: 293-301. PMID: 15682443
11. Bcl10 can promote survival of antigen-stimulated B lymphocytes.  |  Tian, MT., et al. 2005. Blood. 106: 2105-12. PMID: 15878976
12. Bcl10 plays a divergent role in NK cell-mediated cytotoxicity and cytokine generation.  |  Malarkannan, S., et al. 2007. J Immunol. 179: 3752-62. PMID: 17785812

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-Bcl10 Antibody (6D3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-p-Bcl10 Antibody (6D3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-Bcl10 Antibody (6D3) Specifications

Alternate Product Name: Bcl10

Product Clone Name: 6D3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: Ser 138

Epitope Target: Bcl10

Epitope Species: human

Product Reactivity/Detection: Ser 138 phosphorylated Bcl10

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin, PEG and sucrose

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for p-Bcl10 Antibody (6D3): N/A

The preferred Bcl10 antibody is Bcl10 Antibody (331.3): sc-5273.