p-APMSF, Hydrochloride CAS: 74938-88-8
MF: C8H9FN2O2S•HCl
MW: 252.69
An irreversible and specific protease inhibitor.

p-APMSF, Hydrochloride (CAS 74938-88-8)

p-APMSF, Hydrochloride | CAS 74938-88-8 is rated 5.0 out of 5 by 1.
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Synonym: 4-Amidinophenylmethanesulphonyl fluoride hydrochloride
Application: An irreversible and specific protease inhibitor
CAS Number: 74938-88-8
Purity: ≥95%
Molecular Weight: 252.69
Molecular Formula: C8H9FN2O2S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

p-APMSF has been shown to be an irreversible and specific inhibitor of the class of plasma serine proteases which display substrate specificity for positively charged side chains of arginine and lysine amino acids. In addition, p-APMSF has been noted to be a protease inhibitor that blocks intracellular acidification, DNA fragmentation, and 5-Fluoro-2'-deoxyuridine induced cell death in mouse mammary tumor cells. This compound also demonstrates inhibitory abilities toward esterase activity in thrombin like enzymes. p-APMSF, Hydrochloride is an inhibitor of KLK11, Thrombin, Trypsin, C1r, C1s, Factor X and plasminogen.


References

1. Laura, R., et al. 1980. Biochemistry. 19: 4859-4864. PMID: 6775696
2. Cole, T.C., et al. 1989. Biochim. Biophys. Acta. 990: 254-262. PMID: 2923905
3. Nagano, A., et al. 1997. Nucleic Acids Symp. Ser. 135-136. PMID: 9586036
4. Oyama, E., et al. 2003. Toxicon. 41: 559-568. PMID: 12676434

Physical State :
Solid
Solubility :
Soluble in water (50 mM,stable when aliquoted at -20°C. Half-life = 6 minutes in pH 7.0 buffer systems.), DMSO (50 mg/ml), and dimethyl sulfoxide.
Storage :
Store at 4° C
Melting Point :
205° C (dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16218950
MDL Number :
MFCD00078902
Beilstein Registry :
9083148
SMILES :
C1=CC(=CC=C1CS(=O)(=O)F)C(=N)N.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Goller SP; et al Goller SP; et al. (PubMed ID: 9726860) determined that p-APMSF, Hydrochloride irreversibly inhibited dibasic endopeptidase activity. -SCBT Publication Review
Date published: 2015-02-15
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