p-Annexin I Antibody (86.Tyr 21): sc-135751

p-Annexin I Antibody (86.Tyr 21) is a mouse monoclonal IgG1 antibody that detects p-Annexin I in human samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). p-Annexin I plays a crucial role in the regulation of inflammation and cellular signaling, particularly as a mediator of the anti-inflammatory response induced by glucocorticoids. p-Annexin I is primarily located in the cytoplasm and can translocate to the cell membrane in response to calcium ions, which is vital for function in cellular processes such as membrane repair and apoptosis. The ability of p-Annexin I to bind to phospholipids in a calcium-dependent manner underscores importance in maintaining cellular integrity and facilitating the resolution of inflammation. Additionally, p-Annexin I undergoes post-translational modifications, including phosphorylation by protein kinase C, epidermal growth factor receptor, and LTRPC7, which can influence activity and interactions with other proteins. anti-p-Annexin I antibody (86.Tyr 21) is an essential tool for researchers studying the complex roles of Annexin proteins in health and disease, particularly in the context of inflammatory responses and cellular signaling pathways.

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p-Annexin I Antibody (86.Tyr 21) References:

1. Purification, identification and phosphorylation of annexin I from rat liver mitochondria.  |  Yoshii, K., et al. 2000. Acta Med Okayama. 54: 57-65. PMID: 10806526
2. Histidine phosphorylation of annexin I in airway epithelia.  |  Muimo, R., et al. 2000. J Biol Chem. 275: 36632-6. PMID: 10956639
3. Identification and characterization of columbid annexin Icp37. Insights into the evolution of annexin I phosphorylation sites.  |  Haigler, HT., et al. 1992. J Biol Chem. 267: 19123-9. PMID: 1388165
4. Regulation of the chromaffin granule aggregating activity of annexin I by phosphorylation.  |  Wang, W. and Creutz, CE. 1992. Biochemistry. 31: 9934-9. PMID: 1390776
5. Phosphorylation of annexin I by TRPM7 channel-kinase.  |  Dorovkov, MV. and Ryazanov, AG. 2004. J Biol Chem. 279: 50643-6. PMID: 15485879
6. Sustained effect of angiotensin II on tyrosine phosphorylation of annexin I in glomerular mesangial cells.  |  Salles, JP., et al. 1993. J Biol Chem. 268: 12805-11. PMID: 7685351
7. Annexin I is phosphorylated in the multivesicular body during the processing of the epidermal growth factor receptor.  |  Futter, CE., et al. 1993. J Cell Biol. 120: 77-83. PMID: 8093248
8. Change in the N-terminal domain conformation of annexin I that correlates with liposome aggregation is impaired by Ser-27 to Glu mutation that mimics phosphorylation.  |  Porte, F., et al. 1996. Biochim Biophys Acta. 1293: 177-84. PMID: 8620027
9. Translocation of annexin I to plasma membranes and phagosomes in human neutrophils upon stimulation with opsonized zymosan: possible role in phagosome function.  |  Kaufman, M., et al. 1996. Biochem J. 316 (Pt 1): 35-42. PMID: 8645229
10. Growth hormone induces tyrosine phosphorylation of annexin I in rat osteosarcoma cells.  |  Salles, JP., et al. 1996. Endocrinology. 137: 4358-62. PMID: 8828496

The preferred Annexin I antibody is Annexin I Antibody (EH17a): sc-12740.