p-Aminohippuric acid (CAS 61-78-9)
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p-Aminohippuric acid (PAH) is an organic compound structurally characterized by an amino group attached to the para position of a hippuric acid molecule. Hippuric acid itself consists of a benzene ring conjugated to a carboxylic acid and an amide group, forming a non-proteinogenic amino acid derivative. In chemical studies, p-Aminohippuric acid is often used to study kidney functions, particularly renal plasma flow and tubular secretion mechanisms, due to its rapid clearance from circulation almost exclusively by the kidneys. It serves as a marker or probe in physiological experiments to measure renal function because it is both filtered and secreted by the renal tubules, making it useful for assessing the efficiency of the renal system. Additionally, the presence of both amide and carboxyl functional groups in p-Aminohippuric acid allows for a variety of chemical reactions, including conjugation and amidation, making it a useful compound in biochemical synthesis. The amino group enhances its reactivity, facilitating the derivation of more complex compounds used in further research and chemical applications.
p-Aminohippuric acid (CAS 61-78-9) References
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- Secretory transport of p-aminohippuric acid across intestinal epithelial cells in Caco-2 cells and isolated intestinal tissue. | Naruhashi, K., et al. 2001. J Pharm Pharmacol. 53: 73-81. PMID: 11206195
- Alternative high-performance liquid chromatographic assay for p-aminohippuric acid (PAH): effect of aging on PAH excretion in the isolated perfused rat kidney. | Savant, IA., et al. 2001. J Pharm Biomed Anal. 26: 687-99. PMID: 11600282
- Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier. | Kikuchi, R., et al. 2003. J Pharmacol Exp Ther. 306: 51-8. PMID: 12684544
- A new HPLC method to determine glomerular filtration rate and effective renal plasma flow in conscious dogs by single intravenous administration of iohexol and p-aminohippuric acid. | Meucci, V., et al. 2004. J Chromatogr Sci. 42: 107-11. PMID: 15023265
- Determination of uric acid and p-aminohippuric acid in human saliva and urine using capillary electrophoresis with electrochemical detection: potential application in fast diagnosis of renal disease. | Guan, Y., et al. 2005. J Chromatogr B Analyt Technol Biomed Life Sci. 821: 229-34. PMID: 15916928
- Simple HPLC-UV method for determination of iohexol, iothalamate, p-aminohippuric acid and n-acetyl-p-aminohippuric acid in human plasma and urine with ERPF, GFR and ERPF/GFR ratio determination using colorimetric analysis. | Farthing, D., et al. 2005. J Chromatogr B Analyt Technol Biomed Life Sci. 826: 267-72. PMID: 16169291
- Determination of p-aminohippuric acid in rat plasma by liquid chromatography-tandem mass spectrometry. | Fan, HY., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 1643-6. PMID: 20439170
- Development and validation of a liquid chromatography-tandem mass spectrometry method for simultaneous quantification of p-aminohippuric acid and inulin in rat plasma for renal function study. | Lin, CC., et al. 2010. Anal Bioanal Chem. 398: 857-65. PMID: 20652556
- Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy. | Tseng, CS., et al. 2011. Adv Pharmacol Sci. 2011: 204501. PMID: 21738526
- Protein adsorption behavior and immunoglobulin separation with a mixed-mode resin based on p-aminohippuric acid. | Yan, J., et al. 2014. J Sep Sci. 37: 2474-80. PMID: 25044484
- A novel, simple and inexpensive procedure for the simultaneous determination of iopamidol and p-aminohippuric acid for renal function assessment from plasma samples in awake rats. | Rodríguez-Romero, V., et al. 2015. J Pharm Biomed Anal. 107: 196-203. PMID: 25594899
- Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid and creatinine in porcine and broiler chicken plasma. | Dhondt, L., et al. 2019. J Chromatogr B Analyt Technol Biomed Life Sci. 1117: 77-85. PMID: 31004849
- Corrigendum to 'Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid and creatinine in porcine and broiler chicken plasma' [J. Chromatogr. B 1117 (2019) 77-85]. | Dhondt, L., et al. 2019. J Chromatogr B Analyt Technol Biomed Life Sci. 1124: 375. PMID: 31151834
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Aminohippuric acid, 10 g | sc-250625 | 10 g | $117.00 |