Molecular structure of p-Acetamidophenyl β-D-glucuronide sodium salt, CAS Number: 120595-80-4
p-Acetamidophenyl β-D-glucuronide sodium salt (CAS 120595-80-4)
See product citations (4)
Alternate Names:
p-Acetamidophenyl β-D-glucuronide sodium salt is also known as Paracetamol glucuronide.
Application:
p-Acetamidophenyl β-D-glucuronide sodium salt is a metabolite of acetaminophen used as a reference material to indicate hepatotoxicity in urine and plasma analysis.
CAS Number:
120595-80-4
Purity:
98%
Molecular Weight:
349.27
Molecular Formula:
C14H16NO8•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
p-Acetamidophenyl β-D-glucuronide sodium salt is a compound utilized primarily in biochemical assays that involve the study of enzymatic activity, specifically glucuronidase enzymes. This substrate is relevant in enzyme kinetics research where it is hydrolyzed by β-glucuronidase, leading to the release of a chromophoric or fluorogenic product that can be quantitatively measured. In environmental toxicology, p-Acetamidophenyl β-D-glucuronide sodium salt is used in the assessment of microbial activity in soil, as the presence of glucuronidase enzymes can be an indicator of microbial health and pollutant biodegradation. Additionally, the compound is employed in the field of molecular biology for the detection and quantification of β-glucuronidase expression, which can be a marker for gene expression in reporter assays. Its water-solubility, imparted by the sodium salt form, makes it convenient for use in various aqueous-based experimental systems.
p-Acetamidophenyl β-D-glucuronide sodium salt (CAS 120595-80-4) References
- A unique multifunctional transporter translocates estradiol-17beta -glucuronide in rat liver microsomal vesicles. | Battaglia, E. and Gollan, J. 2001. J Biol Chem. 276: 23492-8. PMID: 11313362
- A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression. | Zhou, X., et al. 2011. Mol Pharmacol. 79: 710-23. PMID: 21252290
- Simultaneous quantitative determination of paracetamol and its glucuronide conjugate in human plasma and urine by liquid chromatography coupled to electrospray tandem mass spectrometry: application to a clinical pharmacokinetic study. | Tan, QY., et al. 2012. J Chromatogr B Analyt Technol Biomed Life Sci. 893-894: 162-7. PMID: 22445307
- A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification. | Iverson, SV., et al. 2013. Free Radic Biol Med. 63: 369-80. PMID: 23743293
- LC-MS/MS analysis of uncommon paracetamol metabolites derived through in vitro polymerization and nitration reactions in liquid nitrogen. | Trettin, A., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 966: 171-8. PMID: 24365200
- Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity. | Dubbelman, AC., et al. 2014. J Chromatogr A. 1374: 122-133. PMID: 25435462
- Influence of age on the absorption, metabolism, and excretion of cocoa flavanols in healthy subjects. | Rodriguez-Mateos, A., et al. 2015. Mol Nutr Food Res. 59: 1504-12. PMID: 25981347
- Identification of Carboxylate, Phosphate, and Phenoxide Functionalities in Deprotonated Molecules Related to Drug Metabolites via Ion-Molecule Reactions with water and Diethylhydroxyborane. | Zhu, H., et al. 2017. J Am Soc Mass Spectrom. 28: 2189-2200. PMID: 28741125
- A Novel In Vitro Experimental System for the Evaluation of Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Cryopreserved Human Hepatocytes). | Li, AP., et al. 2018. Drug Metab Dispos. 46: 1608-1616. PMID: 29363498
- Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity. | Li, AP., et al. 2018. Drug Metab Dispos. 46: 1562-1571. PMID: 30006371
- Development of a Multimatrix UHPLC-MS/MS Method for the Determination of Paracetamol and Its Metabolites in Animal Tissues. | Pietruk, K., et al. 2021. Molecules. 26: PMID: 33918518
- Phenelzine and Amoxapine Inhibit Tyramine and d-Glucuronic Acid Catabolism in Clinically Significant Salmonella in A Serotype-Independent Manner. | Burin, R. and Shah, DH. 2021. Pathogens. 10: PMID: 33924374
- SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM1. | Tomabechi, R., et al. 2022. PNAS Nexus. 1: pgac063. PMID: 36741448
- Rapid detection and quantification of paracetamol and its major metabolites using surface enhanced Raman scattering. | AlMasoud, N., et al. 2023. Analyst. 148: 1805-1814. PMID: 36938623
- NMR Studies of electrostatic fields around charged monosaccharides and related molecules | Robert Glaser, Artem Novoselsky, Alexander Shames, Gertz I. Likhtenshtein. 2001. Israel Journal. 40: 263-269.
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Chromogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Acetamidophenyl β-D-glucuronide sodium salt, 10 mg | sc-222105 | 10 mg | $117.00 | |||
p-Acetamidophenyl β-D-glucuronide sodium salt, 25 mg | sc-222105C | 25 mg | $280.00 | |||
p-Acetamidophenyl β-D-glucuronide sodium salt, 50 mg | sc-222105A | 50 mg | $403.00 | |||
p-Acetamidophenyl β-D-glucuronide sodium salt, 100 mg | sc-222105D | 100 mg | $632.00 | |||
p-Acetamidophenyl β-D-glucuronide sodium salt, 250 mg | sc-222105B | 250 mg | $1204.00 |