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Oxyphenonium bromide (CAS 50-10-2)

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Application:
Oxyphenonium bromide is a quaternary ammonium antimuscarinic and anticholinergic agent
CAS Number:
50-10-2
Purity:
≥98%
Molecular Weight:
428.40
Molecular Formula:
C21H34NO3Br
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Oxyphenonium bromide is a quaternary ammonium compound primarily recognized within the research community for its interactions with muscarinic acetylcholine receptors. As a research chemical, it is utilized in studies to investigate the blocking effects on muscarinic receptors, which are pivotal in understanding the modulation of the parasympathetic nervous system. Its specificity and action as an antagonist make it a useful tool in experiments examining the autonomic control of organ systems, including the gastrointestinal and cardiovascular systems. In studies pertaining to smooth muscle physiology, oxyphenonium bromide is employed to discern the role of muscarinic receptors in muscle contractility and to explore the signal transduction mechanisms involved. Additionally, it serves as a comparative standard in the synthesis and characterization of new muscarinic receptor antagonists.


Oxyphenonium bromide (CAS 50-10-2) References

  1. [Software development for calculation of molecular surface area and its application to hydrophobic interaction].  |  Ishikawa, S. 2001. Yakugaku Zasshi. 121: 47-63. PMID: 11201162
  2. Stoichiometric and microenvironmental effects on hydrolysis of propantheline and oxyphenonium bromides in cyclodextrin solutions.  |  Funasaki, N., et al. 2001. J Pharm Sci. 90: 740-8. PMID: 11357177
  3. Solution structures of 1:1 complexes of oxyphenonium bromide with beta- and gamma-cyclodextrins.  |  Funasaki, N., et al. 2004. Mol Pharm. 1: 166-72. PMID: 15832513
  4. Effects of muscarinic antagonists on ZENK expression in the chicken retina.  |  Bitzer, M., et al. 2006. Exp Eye Res. 82: 379-88. PMID: 16143326
  5. Stability-indicating method for determination of oxyphenonium bromide and its degradation product by high-performance liquid chromatography.  |  El-Gindy, A., et al. 2007. J AOAC Int. 90: 1250-7. PMID: 17955969
  6. Quantitative estimation of the bitter taste intensity of oxyphenonium bromide reduced by cyclodextrins from electromotive force measurements.  |  Funasaki, N., et al. 1999. Anal Chem. 71: 1733-6. PMID: 21662814
  7. Urinary bladder effects after oral dosages of the antidiarrhoeal drug (clioquinol/phanquinone/oxyphenonium bromide) in experimental dogs.  |  Chaiyabutr, N., et al. 1985. J Med Assoc Thai. 68: 649-53. PMID: 2937868
  8. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro.  |  Carr, BJ., et al. 2018. Invest Ophthalmol Vis Sci. 59: 2778-2791. PMID: 29860464
  9. Determination of oxyphenonium bromide in plasma and urine by means of ion-pair extraction, derivatization and gas chromatography-electron-capture detection.  |  Greving, JE., et al. 1977. J Chromatogr. 142: 611-9. PMID: 410817
  10. Protective effect of oral oxyphenonium bromide, terbutaline and theophylline against the bronchial obstructive effects of inhaled histamine, acetylcholine and propranolol.  |  Koëter, GH., et al. 1984. Eur J Clin Pharmacol. 26: 435-41. PMID: 6329769
  11. Safety pharmacology of a combination of tinidazole and oxyphenonium bromide.  |  Joseph, T., et al. 1997. Arzneimittelforschung. 47: 869-72. PMID: 9272247
  12. Atropine substitutes and the writhing syndrome in mice.  |  Kelkar, MS. 1977. Arch Int Pharmacodyn Ther. 229: 133-7. PMID: 931459
  13. Hepatic transport of the magnetic resonance imaging contrast agent gadobenate dimeglumine in the rat.  |  de Haën, C., et al. 1995. Acad Radiol. 2: 232-8. PMID: 9419554

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Oxyphenonium bromide, 1 g

sc-281114
1 g
$110.00

Oxyphenonium bromide, 5 g

sc-281114A
5 g
$273.00