Molecular structure of Oxyphenbutazone, CAS Number: 129-20-4
Oxyphenbutazone (CAS 129-20-4)
Alternate Names:
4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione
Application:
Oxyphenbutazone is a non-steroidal anti-inflammatory agent
CAS Number:
129-20-4
Molecular Weight:
324.37
Molecular Formula:
C19H20N2O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Oxyphenbutazone is a metabolite of Phenylbutazone (sc-204843). Oxyphenbutazone differs from the parent compound by a 4-hydroxyl substitution on one phenyl ring. Oxyphenbutazone is described to produce anti-inflammatory effects and demonstrates inhibition of cytokine production.
Oxyphenbutazone (CAS 129-20-4) References
- Simultaneous determination of hydrocortisone, dexamethasone, indomethacin, phenylbutazone and oxyphenbutazone in equine serum by high-performance liquid chromatography. | Grippa, E., et al. 2000. J Chromatogr B Biomed Sci Appl. 738: 17-25. PMID: 10778922
- Pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in miniature donkeys. | Matthews, NS., et al. 2001. Am J Vet Res. 62: 673-5. PMID: 11341383
- Interactions of oxyphenbutazone with different cyclodextrins in aqueous medium and in the solid state. | Veiga, MD. and Merino, M. 2002. J Pharm Biomed Anal. 28: 973-82. PMID: 12039640
- Pharmacodynamics and pharmacokinetics of phenylbutazone in calves. | Arifah, AK. and Lees, P. 2002. J Vet Pharmacol Ther. 25: 299-309. PMID: 12213119
- Phospholipase A2 as a target protein for nonsteroidal anti-inflammatory drugs (NSAIDS): crystal structure of the complex formed between phospholipase A2 and oxyphenbutazone at 1.6 A resolution. | Singh, N., et al. 2004. Biochemistry. 43: 14577-83. PMID: 15544328
- 4-Hydroxy-oxyphenbutazone is a potent inhibitor of cytokine production. | Ten Brinke, A., et al. 2005. Eur Cytokine Netw. 16: 144-51. PMID: 15941686
- Screening, quantification, and confirmation of phenylbutazone and oxyphenbutazone in equine plasma by liquid chromatography-tandem mass spectrometry. | You, Y., et al. 2009. J Anal Toxicol. 33: 41-50. PMID: 19161668
- Chemopreventive activities of etodolac and oxyphenbutazone against mouse skin carcinogenesis. | Kapadia, GJ., et al. 2010. Bioorg Med Chem Lett. 20: 2546-8. PMID: 20299217
- Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. | Gold, B., et al. 2012. Proc Natl Acad Sci U S A. 109: 16004-11. PMID: 23012453
- Quantification of several acidic drugs in equine serum using LC-MS-MS. | Heffron, B., et al. 2013. J Anal Toxicol. 37: 600-4. PMID: 23983013
- Analysis of phenylbutazone residues in horse tissues with and without enzyme-hydrolysis by LC-MS/MS. | Boison, JO., et al. 2016. Drug Test Anal. 8: 535-8. PMID: 27443208
- The Analysis of Phenylbutazone and Its Active Metabolite, Oxyphenbutazone, in Equine Tissues (Muscle, Kidney, and Liver), Urine, and Serum by LC-MS/MS. | Boison, JO., et al. 2017. J AOAC Int. 100: 1110-1122. PMID: 28145218
- Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway. | Saleem, S., et al. 2018. Mol Cell Biochem. 444: 187-196. PMID: 29204817
- Comparative pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in clinically normal horses and donkeys. | Mealey, KL., et al. 1997. Am J Vet Res. 58: 53-5. PMID: 8989496
- Pharmacokinetic and pharmacodynamic studies on phenylbutazone and oxyphenbutazone in goats. | Cheng, Z., et al. 1997. Vet Rec. 140: 40-3. PMID: 9123796
Inhibitor of:
group XIIA sPLA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oxyphenbutazone, 25 mg | sc-212491 | 25 mg | $282.00 | |||
Oxyphenbutazone, 50 mg | sc-212491A | 50 mg | $578.00 | |||
Oxyphenbutazone, 100 mg | sc-212491B | 100 mg | $1028.00 |