Oxymetazoline Hydrochloride CAS: 2315-02-8
MF: C16H24N2O•HCl
MW: 296.84
An α1-AR and α2-AR adrenergic receptor agonist..

Oxymetazoline Hydrochloride (CAS 2315-02-8)

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Application: Oxymetazoline Hydrochloride is is an α1-AR and α2-AR adrenergic receptor agonist.
CAS Number: 2315-02-8
Molecular Weight: 296.84
Molecular Formula: C16H24N2O•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Oxymetazoline Hydrochloride is a direct sympathomimetic agent. Is a nonselective adrenomimetic of α1A-AR and α2A-AR (α1-AR and α2-AR adrenergic receptor) agonists. Since vascular beds widely express α1 receptors, the action of Oxymetazoline results in vasoconstriction due to its action on endothelial α2 receptors. Oxymetazoline Hydrochloride is an inhibitor of SR-2C and an activator of SR-1A, SR-1B, SR-1D and SR-2C.


References

1. Schoeffter, P., et al. 1991. Eur. J. Pharmacol. 196: 213-216. PMID: 1678720
2. Horie, K., et al. 1995. Br. J. Pharmacol. 116: 1611-1618. PMID: 8564227
3. Widdicombe, J. 1997. Allergy. 52: 7-11. PMID: 9353554
4. Bayorh, M.A., et al. 1997. Clin. Exp. Hypertens. 18: 445-460. PMID: 9140707

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), alcohol (1: 3.6), methanol, DMSO (59 mg/ml), and ethanol (59 mg/ml).
Storage :
Store at room temperature
Melting Point :
>300° C
Boiling Point :
431.9° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
5-HT1b: IC50 = 2 nM (rat); Adrenergic receptor alpha-2: IC50 = 5 nM (rat); SR-1A: EC5050 = 70 nM (human); Short transient receptor potential channel 4: EC5050 = 3.35 µM (mouse); Plasmodium falciparum: IC50 = 10 µM
Ki Data :
SR-1B: Ki= 0.3 nM (human); SR-1D: Ki= 0.4 nM (human); α1A adrenoceptor: Ki= 6 nM; α1B adrenoceptor: Ki= 320 nM; α1C adrenoceptor: Ki= 390 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
66259
Merck Index :
14: 6966
MDL Number :
MFCD00058147
EC Number :
219-015-0
SMILES :
CC1=CC(=C(C(=C1CC2=NCCN2)C)O)C(C)(C)C.Cl

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Certificate of Analysis

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Oxymetazoline Hydrochloride (CAS 2315-02-8)  Product Citations

See how others have used Oxymetazoline Hydrochloride (CAS 2315-02-8). Click on the entry to view the PubMed entry .

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PMID: # 14449214  HOTOVY, R. et al. 1961. Arzneimittelforschung. 11: 1016-1022.

Citations 1 to 1 of 1 total

RE:Oxymetazoline Hydrochloride, 5 g sc-203172 - What is the purity of this chemical?

Asked by: Anonymous
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. The purity of the most recent lot for sc-203172 is 99.9%.
Answered by: Tech Service
Date published: 2019-11-27
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