Molecular structure of Oxymatrine, CAS Number: 16837-52-8
Oxymatrine (CAS 16837-52-8)
See product citations (3)
Alternate Names:
Matrine N-oxide; Ammothamnine
Application:
Oxymatrine is an inhibitor of IL-6 and IL-1β mRNA expression
CAS Number:
16837-52-8
Purity:
≥98%
Molecular Weight:
264.37
Molecular Formula:
C15H24N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Oxymatrine is a compound from Sophora japonica, which has many biologically functions such as the inhibition of IL-6 and IL-1beta mRNA expression. Studies indicate that Oxymatrine functions as an inhibitor of hepatitis B virus (HBV) by downregulating the gene coding for heat-stress cognate 70 (Hsc70), which is required for HBV DNA replication. In addition, Oxymatrine inhibits TLR4 (Toll-like receptor 4)/NF-kappaB (nuclear factor kappa-B) and reduce apoptosis in neurons. Furthermore, Oxymatrine acts as an inhibitor of beta-catenin in MCF-7 breast cancer cells via suppressing its expression.
Oxymatrine (CAS 16837-52-8) References
- Oxymatrine diminishes the side population and inhibits the expression of β-catenin in MCF-7 breast cancer cells. | Zhang, Y., et al. 2011. Med Oncol. 28 Suppl 1: S99-107. PMID: 21069479
- Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury. | Dong, XQ., et al. 2011. Inflamm Res. 60: 533-9. PMID: 21190123
- [The effects of oxymatrine on expression of interleukin-6 and interleukin-1beta mRNA of human periodontal ligament cell stimulated by lipopolysaccharides]. | Wu, Y., et al. 2010. Hua Xi Kou Qiang Yi Xue Za Zhi. 28: 656-9. PMID: 21365847
- Protective effect of oxymatrine on myocardial fibrosis induced by acute myocardial infarction in rats involved in TGF-β₁-Smads signal pathway. | Shen, XC., et al. 2011. J Asian Nat Prod Res. 13: 215-24. PMID: 21409682
- Oxymatrine exerts organ- and tissue-protective effects by regulating inflammation, oxidative stress, apoptosis, and fibrosis: From bench to bedside. | Lan, X., et al. 2020. Pharmacol Res. 151: 104541. PMID: 31733326
- Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression. | Jin, Y., et al. 2020. Front Pharmacol. 11: 808. PMID: 32581789
- Oxymatrine Inhibits Colorectal Cancer Metastasis via Attenuating PKM2-Mediated Aerobic Glycolysis. | Li, X., et al. 2020. Cancer Manag Res. 12: 9503-9513. PMID: 33061637
- Oxymatrine attenuates oxidized low‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway. | Jin, X., et al. 2021. Int J Mol Med. 48: PMID: 34368883
- Oxymatrine inhibits neuroinflammation byRegulating M1/M2 polarization in N9 microglia through the TLR4/NF-κB pathway. | Wang, XL., et al. 2021. Int Immunopharmacol. 100: 108139. PMID: 34517275
- Oxymatrine Alleviates Hyperglycemic Cerebral Ischemia/Reperfusion Injury via Protecting Microvessel. | Wang, WJ., et al. 2022. Neurochem Res. 47: 1369-1382. PMID: 35099719
- Oxymatrine attenuates TNBS-induced colinutis in rats through TLR9/Myd88/NF-κB signal pathway. | Li, S., et al. 2022. Hum Exp Toxicol. 41: 9603271221078866. PMID: 35290143
- Oxymatrine inhibits the pyroptosis in rat insulinoma cells by affecting nuclear factor kappa B and nuclear factor (erythroid-derived 2)-like 2 protein/heme oxygenase-1 pathways. | Gao, J., et al. 2022. Korean J Physiol Pharmacol. 26: 165-174. PMID: 35477544
- Oxymatrine suppresses oral squamous cell carcinoma progression by suppressing CXC chemokine receptor 4 in an m6A modification decrease dependent manner. | Luo, R., et al. 2022. Oncol Rep. 48: PMID: 36004481
- Oxymatrine Alleviates Gentamicin-Induced Renal Injury in Rats. | Kang, S., et al. 2022. Molecules. 27: PMID: 36234739
- Oxymatrine and insulin resistance: Focusing on mechanistic intricacies involve in diabetes associated cardiomyopathy via SIRT1/AMPK and TGF-β signaling pathway. | Seksaria, S., et al. 2023. J Biochem Mol Toxicol. 37: e23330. PMID: 36890713
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oxymatrine, 100 mg | sc-279937 | 100 mg | $110.00 | |||
Oxymatrine, 1 g | sc-279937A | 1 g | $323.00 |