Molecular structure of Oxy-16, CAS Number: 596-94-1
Oxy-16 (CAS 596-94-1)
Alternate Names:
(3β,22R)-Dihydroxy Cholesterol
Application:
Oxy-16 is a synthetic oxysterol compound and Hedgehog signaling pathway activator
CAS Number:
596-94-1
Purity:
>95%
Molecular Weight:
418.7
Molecular Formula:
C27H46O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Oxy-16, an oxysterol, is a cell permeable oxygenated derivative of cholesterol that may be the end product or intermediate of the cholesterol excretion pathways. This compound is at times used as a form of transport for cholesterol across the blood brain barrier and membranes. Oxysterols have also been shown to be involved in apoptosis, immunosuppression, inflammation, atherosclerosis, and cholesterol turnover. Further studies show that oxysterols are Hedgehog (Hh) signaling pathway activators and contain potent osteoinductive properties. The osteogenic differentiation caused by this compound is thought to be mediated through a Wnt signaling-related, Dkk-1-inhibitable mechanism.
Oxy-16 (CAS 596-94-1) References
- Oxysterols: friends, foes, or just fellow passengers? | Björkhem, I. and Diczfalusy, U. 2002. Arterioscler Thromb Vasc Biol. 22: 734-42. PMID: 12006384
- Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. | Dwyer, JR., et al. 2007. J Biol Chem. 282: 8959-68. PMID: 17200122
- Oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by Dkk-1 inhibitable and PI3-kinase mediated signaling. | Amantea, CM., et al. 2008. J Cell Biochem. 105: 424-36. PMID: 18613030
- Potent growth inhibitory activity of a novel Ornithogalum cholestane glycoside on human cells: induction of apoptosis in promyelocytic leukemia HL-60 cells. | Hirano, T., et al. 1996. Life Sci. 58: 789-98. PMID: 8632726
Activator of:
Su(fu).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oxy-16, 1 mg | sc-358805 | 1 mg | $205.00 | |||
Oxy-16, 5 mg | sc-358805A | 5 mg | $921.00 |