Molecular structure of Oxolinic Acid, CAS Number: 14698-29-4
Oxolinic Acid (CAS 14698-29-4)
See product citations (3)
Alternate Names:
5,8-Dihydro-5-ethyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid
Application:
Oxolinic Acid is a quinoline antibacterial compound and inhibitor of Topo II
CAS Number:
14698-29-4
Purity:
≥98%
Molecular Weight:
261.23
Molecular Formula:
C13H11NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Oxolinic acid, a quinolone antibiotic, selectively targets bacterial DNA gyrase while sparing eukaryotic topoisomerases. It achieves this by binding reversibly to subunit A within the gyrase-DNA complexes, thereby impeding supercoiling activity and suppressing DNA synthesis within the range of 0.5-5 µg/ml. Furthermore, oxolinic acid hinders the neuronal uptake of dopamine in mammals (with an IC50 value of 4.3 µM), resulting in heightened locomotor activity.
Oxolinic Acid (CAS 14698-29-4) References
- Efficacy of orally administered oxolinic acid and Vetoquinol, an oxolinic acid ester, for the treatment of furunculosis in Atlantic salmon Salmo salar held in seawater. | Samuelsen, OB., et al. 1999. Dis Aquat Organ. 37: 53-9. PMID: 10439903
- Determination of oxolinic acid in the bryophyte Fontinalis antipyretica by liquid chromatography with fluorescence detection. | Delépée, R. and Pouliquen, H. 2002. J Chromatogr B Analyt Technol Biomed Life Sci. 775: 89-95. PMID: 12101064
- A single-dose pharmacokinetic study of oxolinic acid and vetoquinol, an oxolinic acid ester, in cod, Gadus morhua L., held in sea water at 8 degrees C and in vitro antibacterial activity of oxolinic acid against Vibrio anguillarum strains isolated from diseased cod. | Samuelsen, OB., et al. 2003. J Fish Dis. 26: 339-47. PMID: 12899409
- Oxolinic acid photo-oxidation using immobilized TiO(2). | Palominos, RA., et al. 2008. J Hazard Mater. 158: 460-4. PMID: 18400380
- Pharmacokinetic Data Show That Oxolinic Acid and Flumequine Are Absorbed and Excreted Rapidly From Plasma and Tissues of Lumpfish. | Haugland, GT., et al. 2019. Front Vet Sci. 6: 394. PMID: 31781582
- Photodegradation of oxolinic acid in aquaculture effluents under solar irradiation: is it possible to enhance efficiency by the use of TiO2/carbon quantum dots composites? | Silva, V., et al. 2022. Chemosphere. 308: 136522. PMID: 36150486
- Survey of Oxolinic Acid-Resistant Erwinia amylovora in Korean Apple and Pear Orchards, and the Fitness Impact of Constructed Mutants. | Ham, H., et al. 2022. Plant Pathol J. 38: 482-489. PMID: 36221920
- Comparative metabolism of oxolinic acid by the rat, rabbit and dog. | Crew, MC., et al. 1971. Xenobiotica. 1: 193-201. PMID: 5173021
- Biotransformation of the methylenedioxy moeity of oxolinic acid in man. | DiCarlo, FJ., et al. 1968. Arch Biochem Biophys. 127: 503-11. PMID: 5698001
- Oxolinic acid and diazepam: their reciprocal antagonism in rodents. | Thiébot, MH., et al. 1980. Psychopharmacology (Berl). 67: 91-5. PMID: 6768084
- Nalidixic acid, oxolinic acid, and novobiocin inhibit yeast glycyl- and leucyl-transfer RNA synthetases. | Wright, HT., et al. 1981. Science. 213: 455-6. PMID: 7017932
- Effects of oxolinic acid on the sleep-wakefulness cycle of the rat. | D'Angelo, L. and Monti, JM. 1981. Br J Pharmacol. 74: 399-404. PMID: 7317689
- Carcinogenicity studies of oxolinic acid in rats and mice. | Yamada, T., et al. 1994. Food Chem Toxicol. 32: 397-408. PMID: 8206438
Inhibitor of:
Topo II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oxolinic Acid, 1 g | sc-212488 | 1 g | $107.00 |