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Oxiconazole Nitrate (CAS 64211-46-7)

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Alternate Names:
Myfungar; Oceral; Oxistat; Okiconale
Application:
Oxiconazole Nitrate is an antifungal agent
CAS Number:
64211-46-7
Molecular Weight:
492.14
Molecular Formula:
C18H13Cl4N3O•HNO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Oxiconazole nitrate is a compound extensively studied in the disciplines of organic chemistry and materials science, particularly for its role in the understanding of antifungal mechanisms at a molecular level. As an azole derivative, it provides researchers with a model to study the inhibition of lanosterol 14α-demethylase, an enzyme critical to ergosterol biosynthesis in fungi, which is for maintaining fungal cell membrane integrity. Investigations into the interaction between oxiconazole nitrate and the fungal enzyme contribute to the broader knowledge of azole-enzyme binding dynamics and resistance development. The nitrate salt form of oxiconazole, with its enhanced solubility characteristics, is particularly useful in formulating it into different substrates and studying its stability and release kinetics.


Oxiconazole Nitrate (CAS 64211-46-7) References

  1. [The in vitro properties of a new hydroxypyridone antimycotic rilopirox, with special reference to its anti-Candida activity].  |  Harada, I., et al. 1999. Jpn J Antibiot. 52: 146-52. PMID: 10221179
  2. Oxiconazole nitrate: pharmacology, efficacy, and safety of a new imidazole antifungal agent.  |  Jegasothy, BV. and Pakes, GE. 1991. Clin Ther. 13: 126-41. PMID: 2029718
  3. Efficacy of topical antifungals in the treatment of dermatophytosis: a mixed-treatment comparison meta-analysis involving 14 treatments.  |  Rotta, I., et al. 2013. JAMA Dermatol. 149: 341-9. PMID: 23553036
  4. Evaluation of a novel oxiconazole nitrate formulation: The thermosensitive gel.  |  Arslan, A., et al. 2018. Saudi Pharm J. 26: 665-672. PMID: 29991910
  5. Skin Targeting of Oxiconazole Nitrate Loaded Nanostructured Lipid- Carrier Gel for Fungal Infections.  |  Ranpise, HA., et al. 2018. Pharm Nanotechnol. 6: 192-200. PMID: 30210010
  6. Further in vitro studies with oxiconazole nitrate.  |  Shadomy, S., et al. 1988. Diagn Microbiol Infect Dis. 9: 231-7. PMID: 3180708
  7. Superficial fungal infections. Getting rid of lesions that don't want to go away.  |  Kovacs, SO. and Hruza, LL. 1995. Postgrad Med. 98: 61-2, 68-9, 73-5. PMID: 7501581
  8. Response to treatment and recurrence of dermatomycosis in patients with diabetes.  |  Torres, JE., et al. 1993. P R Health Sci J. 12: 189-90. PMID: 8272485
  9. Evaluation of cutaneous reactivity to recently marketed dermatologic products.  |  Shelanski, MV., et al. 1996. Int J Dermatol. 35: 137-40. PMID: 8850048
  10. [In vitro antifungal activity of rilopirox, a new hydroxypyridone antimycotic agent].  |  Harada, I., et al. 1997. Jpn J Antibiot. 50: 195-9. PMID: 9100079

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Oxiconazole Nitrate, 1 g

sc-205783
1 g
$139.00

Oxiconazole Nitrate, 5 g

sc-205783A
5 g
$417.00