Molecular structure of Oxibendazole, CAS Number: 20559-55-1
Oxibendazole (CAS 20559-55-1)
Alternate Names:
2-Benzimidazolecarbamic acid, 5-propoxy-, methyl ester
Application:
Oxibendazole is an anthelmintic heterocyclic compound
CAS Number:
20559-55-1
Molecular Weight:
249.27
Molecular Formula:
C12H15N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Oxibendazole is a compound that is primarily researched in the context of its anthelmintic activity. In studies focusing on parasitology, oxibendazole is used to understand its mode of action, which involves disruption of microtubule dynamics in parasitic worms. The compound is a subject of interest due to its ability to bind to beta-tubulin and inhibit its polymerization, which is essential for the survival and reproduction of helminths. Research also explores the spectrum of activity of oxibendazole against different species of nematodes and its potential for inducing resistance. Additionally, the compound′s kinetic properties, such as absorption, distribution, metabolism, and excretion in non-human subjects, are studied to understand how these factors contribute to its anthelmintic activity.
Oxibendazole (CAS 20559-55-1) References
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- Species-specific identification of equine cyathostomes resistant to fenbendazole and susceptible to oxibendazole and moxidectin by macroarray probing. | Traversa, D., et al. 2009. Exp Parasitol. 121: 92-5. PMID: 18950625
- Seven benzimidazole pesticides combined at sub-threshold levels induce micronuclei in vitro. | Ermler, S., et al. 2013. Mutagenesis. 28: 417-26. PMID: 23547264
- An ultrasonographic scoring method for transabdominal monitoring of ascarid burdens in foals. | Nielsen, MK., et al. 2016. Equine Vet J. 48: 380-6. PMID: 26122402
- Gold Nanoparticle-Based Paper Sensor for Simultaneous Detection of 11 Benzimidazoles by One Monoclonal Antibody. | Guo, L., et al. 2018. Small. 14: PMID: 29266723
- Oxibendazole inhibits prostate cancer cell growth. | Chen, Q., et al. 2018. Oncol Lett. 15: 2218-2226. PMID: 29434928
- Oxibendazole induces apoptotic cell death in proliferating porcine trophectoderm and uterine luminal epithelial cells via mitochondria-mediated calcium disruption and breakdown of mitochondrial membrane potential. | Park, H., et al. 2019. Comp Biochem Physiol C Toxicol Pharmacol. 220: 9-19. PMID: 30822534
- Anthelmintic efficacy of single active and combination products against commonly occurring parasites in foals. | Morris, LH., et al. 2019. Vet Parasitol. 268: 46-52. PMID: 30981305
- Evaluation of activity of fenbendazole, oxibendazole, piperazine , and pyrantel pamoate alone and combinations against ascarids, strongyles, and strongyloides in horse foals in field tests on two farms in Central Kentucky in 2014 and 2015. | Lyons, ET., et al. 2016. Vet Parasitol Reg Stud Reports. 3-4: 23-26. PMID: 31014495
- Dealing with double trouble: Combination deworming against double-drug resistant cyathostomins. | Scare, JA., et al. 2020. Int J Parasitol Drugs Drug Resist. 12: 28-34. PMID: 31883485
- Ascarids exposed: a method for in vitro drug exposure and gene expression analysis of anthelmintic naïve Parascaris spp. | Scare, JA., et al. 2020. Parasitology. 147: 659-666. PMID: 32046800
- Importation of macrocyclic lactone resistant cyathostomins on a US thoroughbred farm. | Nielsen, MK., et al. 2020. Int J Parasitol Drugs Drug Resist. 14: 99-104. PMID: 33022574
- Anthelmintic efficacy of oxibendazole against gastrointestinal nematodes in swine. | Mendonça, RP., et al. 2022. Rev Bras Parasitol Vet. 31: e018321. PMID: 35239858
- Clinical trials with fenbendazole and oxibendazole for Strongyloides westeri infection in foals. | Drudge, JH., et al. 1981. Am J Vet Res. 42: 526-7. PMID: 7023296
- A comparison of the anthelmintic effects of oxfendazole and oxibendazole on Trichinella spiralis in mice. | Karunakaran, CS. and Denham, DA. 1980. J Parasitol. 66: 929-32. PMID: 7218114
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oxibendazole, 50 mg | sc-219508 | 50 mg | $153.00 |