Molecular structure of Oxatomide, CAS Number: 60607-34-3
Oxatomide (CAS 60607-34-3)
Alternate Names:
1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one
Application:
Oxatomide is an H1-histamine receptor antagonist
CAS Number:
60607-34-3
Purity:
99%
Molecular Weight:
426.55
Molecular Formula:
C27H30N4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Oxatomide is a phenylpiperazine which acts as an H1 receptor antagonist. An interesting characteristic of Oxatomide is that it does not block acetylcholine in the central and peripheral nervous system. Studies conducted on guines pigs show that Oxatomide suppresses PAF-induced bronchoconstriction and inhibits the release of leukotrienes and other mediators. Alternate studies show that the effectiveness of Oxatomide is not altered as a result of pretreating the cells with histamine, which is observed in other H1 receptor antagonists such as Fexofenadine (sc-218475). It is believed that Oxatomide′s lipophilic properties allow it to cross the plasma membrane of cells.
Oxatomide (CAS 60607-34-3) References
- Effect of oxatomide, an antiallergic agent, on QT interval in dogs. | Iwamoto, K., et al. 2001. Arzneimittelforschung. 51: 971-6. PMID: 11799844
- High-performance liquid chromatographic determination of oxatomide and its metabolite and its application to pharmacokinetic study in rat plasma. | Kikuchi, K., et al. 2002. Arzneimittelforschung. 52: 754-63. PMID: 12442638
- The antiallergic drug oxatomide promotes human eosinophil apoptosis and suppresses IL-5-induced eosinophil survival. | Domae, M., et al. 2003. J Allergy Clin Immunol. 111: 567-72. PMID: 12642838
- Determination of oxatomide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry. | She, X., et al. 2008. Biomed Chromatogr. 22: 746-52. PMID: 18348338
- Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. | Hishinuma, S., et al. 2008. J Pharmacol Sci. 107: 66-79. PMID: 18446005
- P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. | Yoshida, K., et al. 2015. Eur J Pharmacol. 767: 41-51. PMID: 26463039
- Antiallergic Activity of 3-O-Dodecyl-l-ascorbic Acid. | Koga, T., et al. 2023. Molecules. 29: PMID: 38202652
- [Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators]. | Ohmori, K., et al. 1983. Nihon Yakurigaku Zasshi. 81: 399-409. PMID: 6138301
- Effect of oxatomide on experimental allergic rhinitis in guinea pigs. | Kaise, T., et al. 1998. Jpn J Pharmacol. 76: 223-6. PMID: 9541287
- Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils. | Shindo, K. and Fukumura, M. 1998. Prostaglandins Leukot Essent Fatty Acids. 58: 99-104. PMID: 9578146
Inhibitor of:
Histamine H1 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oxatomide, 10 mg | sc-208136 | 10 mg | $200.00 |