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Oxantel pamoate (CAS 68813-55-8)

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Alternate Names:
Oxantel embonate
CAS Number:
68813-55-8
Molecular Weight:
604.65
Molecular Formula:
C13H16N2O•C23H16O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Oxantel pamoate is a chemical compound that functions as an anthelmintic agent in development applications. Its mechanism of action involves disrupting the neuromuscular function of parasitic worms by selectively inhibiting the enzyme fumarate reductase. This inhibition leads to a decrease in the production of adenosine triphosphate (ATP) in the parasites, ultimately causing paralysis and expulsion from the host organism. Oxantel pamoate targets the energy metabolism of the parasites, interfering with their ability to maintain normal muscle function and survival. Oxantel Pamoate′s mechanism of action at the molecular level involves binding to the fumarate reductase enzyme, thereby disrupting the electron transport chain and leading to the depletion of ATP in the parasites. In experimental applications, oxantel pamoate plays a functional role in studying the biochemistry and physiology of parasitic worms, providing insights into potential targets for anthelmintic development.


Oxantel pamoate (CAS 68813-55-8) References

  1. Clinical Trial Of Oxantel Pamoate(Cp-14, 445) On Trichocephalus Trichiurus Infection.  |  Lee, SH., et al. 1976. Kisaengchunghak Chapchi. 14: 25-31. PMID: 12913448
  2. Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug.  |  Keiser, J., et al. 2013. PLoS Negl Trop Dis. 7: e2119. PMID: 23556013
  3. Oxantel pamoate-albendazole for Trichuris trichiura infection.  |  Keiser, J., et al. 2014. N Engl J Med. 370: 1953-4. PMID: 24827042
  4. Oxantel pamoate-albendazole for Trichuris trichiura infection.  |  Yasukawa, K. 2014. N Engl J Med. 370: 1952. PMID: 24827043
  5. Oxantel pamoate-albendazole for Trichuris trichiura infection.  |  McCarthy, JS. 2014. N Engl J Med. 370: 1952-3. PMID: 24827044
  6. Oxantel pamoate and deworming programmes.  |  Maheu-Giroux, M. 2016. Lancet Infect Dis. 16: 5-6. PMID: 26388170
  7. In Vitro and In Vivo Drug Interaction Study of Two Lead Combinations, Oxantel Pamoate plus Albendazole and Albendazole plus Mebendazole, for the Treatment of Soil-Transmitted Helminthiasis.  |  Cowan, N., et al. 2016. Antimicrob Agents Chemother. 60: 6127-33. PMID: 27480864
  8. Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in vitro and in vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes.  |  Cowan, N., et al. 2017. Int J Parasitol Drugs Drug Resist. 7: 159-173. PMID: 28371660
  9. Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota.  |  Schneeberger, PHH., et al. 2018. Int J Parasitol Drugs Drug Resist. 8: 372-378. PMID: 30007544
  10. Stability investigation of FCC-based tablets for oral suspension with caffeine and oxantel pamoate as model drugs.  |  Wagner-Hattler, L., et al. 2019. Drug Dev Ind Pharm. 45: 222-230. PMID: 30260721
  11. In Vitro and In Vivo Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine.  |  Neodo, A., et al. 2019. Antimicrob Agents Chemother. 63: PMID: 30323047
  12. Preclinical and Clinical Characteristics of the Trichuricidal Drug Oxantel Pamoate and Clinical Development Plans: A Review.  |  Palmeirim, MS., et al. 2021. Drugs. 81: 907-921. PMID: 33929716
  13. Therapeutic evaluation of oxantel pamoate (1, 4, 5, 6-tetrahydro-1-methyl-2-[trans-3-hydroxystyryl] pyrimidine pamoate) in severe Trichuris trichiura infection.  |  Lee, EL., et al. 1976. Am J Trop Med Hyg. 25: 563-7. PMID: 961973

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Oxantel pamoate, 1 g

sc-236261
1 g
$28.00