OXA1L Antibody (12): sc-136011
- OXA1L Antibody (12) is a mouse monoclonal IgG2b, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 225-435 of OXA1L of human origin
- recommended for detection of OXA1L of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for OXA1L Antibody (12). This work is in progress.
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OXA1L Antibody (12) is a mouse monoclonal IgG2b antibody that detects OXA1L in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). OXA1L, also known as oxidase (cytochrome c) assembly 1-like, is a crucial 435 amino acid protein located in the mitochondrial inner membrane, where OXA1L plays a vital role in the biogenesis of integral membrane proteins. OXA1L is a member of the Oxa1/Alb3/YidC family, which is evolutionarily conserved and essential for the proper assembly and function of key components of the oxidative phosphorylation system, including cytochrome oxidase and ATP synthase. The correct localization of OXA1L within the mitochondrial inner membrane is critical, as OXA1L facilitates the insertion of these integral membrane proteins, ensuring efficient energy production in cells. Disruptions in the function of OXA1L, often due to mutations in its encoding gene, can lead to severe metabolic disorders characterized by combined enzymatic deficiencies in the oxidative phosphorylation pathway, highlighting the importance of OXA1L in cellular energy metabolism and overall mitochondrial health. Anti-OXA1L antibody (12) is an invaluable tool for researchers studying mitochondrial function and related pathologies.
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OXA1L Antibody (12) References:
- Knockdown of human Oxa1l impairs the biogenesis of F1Fo-ATP synthase and NADH:ubiquinone oxidoreductase. | Stiburek, L., et al. 2007. J Mol Biol. 374: 506-16. PMID: 17936786
- Identification of protein-protein and protein-ribosome interacting regions of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L. | Haque, ME., et al. 2010. J Biol Chem. 285: 34991-8. PMID: 20739282
- OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. | Thompson, K., et al. 2018. EMBO Mol Med. 10: PMID: 30201738
- Purification of Mitochondrial Ribosomes with the Translocase Oxa1L from HEK Cells. | Yang, H. and Desai, N. 2021. Bio Protoc. 11: e4110. PMID: 34458404
- Identification of miRNA-mRNA Regulatory Networks Associated with Diabetic Retinopathy using Bioinformatics Analysis. | Xu, W., et al. 2023. Endocr Metab Immune Disord Drug Targets. 23: 1628-1636. PMID: 37114785
- Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria. | Poerschke, S., et al. 2024. Mol Cell. 84: 345-358.e5. PMID: 38199007
- Mitochondrial protein synthesis quality control. | Koludarova, L. and Battersby, BJ. 2024. Hum Mol Genet. 33: R53-R60. PMID: 38280230
- New variants of the DAD1 and OXA1L genes are associated with asthma and atopy in an adult population. | Pires, AO., et al. 2025. Gene. 937: 149124. PMID: 39615807
- The OXA1L gene that controls cytochrome oxidase assembly maps to the 14q11.2 region of the human genome. | Molina-Gomes, D., et al. 1995. Genomics. 30: 396-8. PMID: 8586451
- Sequence and structure of the human OXA1L gene and its upstream elements. | Rötig, A., et al. 1997. Biochim Biophys Acta. 1361: 6-10. PMID: 9247084
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OXA1L Antibody (12) | sc-136011 | 50 µg/0.5 ml | $322.00 |