Ox40 Antibody (6A371): sc-71769
- Ox40 Antibody (6A371) is a rat monoclonal IgG1 provided at 200 µg/ml
- raised against OX40 of mouse origin
- recommended for detection of Ox40 cell surface antigen of mouse origin by IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ox40 Antibody (6A371). This work is in progress.
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Ox40 Antibody (6A371) is a rat monoclonal IgG1 antibody that detects Ox40 in mouse samples through applications such as immunofluorescence (IF) and flow cytometry (FCM). Ox40, also known as CD134 or Ox40R, plays a crucial role in the immune response by regulating the activation and differentiation of CD4+ T lymphocytes. Anti-Ox40 antibody (6A371) recognizes a protein primarily located on the surface of activated CD4+ T cells, where Ox40 interacts with Ox40L, predominantly expressed on activated B cells. The engagement of Ox40 with Ox40L provides a vital costimulatory signal that enhances T cell activation, promoting effective immune responses. This interaction is particularly important for the generation of robust T helper cell responses, which are essential for orchestrating adaptive immunity and ensuring the body can effectively combat infections and maintain tissue homeostasis. Ox40 (6A371) antibody serves as an invaluable tool for researchers studying T cell dynamics and the underlying mechanisms of immune regulation, making Ox40 (6A371) monoclonal antibody a key asset in the exploration of autoimmune diseases, inflammation, and therapeutic interventions.
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Ox40 Antibody (6A371) References:
- The significance of OX40 and OX40L to T-cell biology and immune disease. | Croft, M., et al. 2009. Immunol Rev. 229: 173-91. PMID: 19426222
- Signaling through OX40 enhances antitumor immunity. | Jensen, SM., et al. 2010. Semin Oncol. 37: 524-32. PMID: 21074068
- Inhibiting OX40 Restores Regulatory T-Cell Function and Suppresses Inflammation in Pulmonary Sarcoidosis. | Kumari, R., et al. 2021. Chest. 160: 969-982. PMID: 33901497
- Prognostic significance of OX40+ lymphocytes in tumor stroma of surgically resected small-cell lung cancer. | Yokouchi, H., et al. 2021. Oncoimmunology. 10: 1971430. PMID: 34552823
- High soluble OX40 levels correlate with metastatic gastric cancer. | Lima, CAC., et al. 2022. J Surg Oncol. 126: 139-143. PMID: 35689573
- Analysis of the OX40/OX40L immunoregulatory axis combined with alternative immune checkpoint molecules in pancreatic ductal adenocarcinoma. | Chen, X., et al. 2022. Front Immunol. 13: 942154. PMID: 35936015
- Ox40-Cre-mediated deletion of BRD4 reveals an unexpected phenotype of hair follicle stem cells in alopecia. | Wen, M., et al. 2022. JCI Insight. 7: PMID: 36256455
- OX40 Ligand-Mannose-Binding Lectin Fusion Protein Induces Potent OX40 Cosignaling in CD4+ T Cells. | Sato, A., et al. 2022. Biol Pharm Bull. 45: 1798-1804. PMID: 36450532
- Noninvasive Imaging OX40+ Activated T Cells Provides Early Warning of Rheumatoid Arthritis. | Wen, G., et al. 2023. Mol Imaging Biol. 25: 621-629. PMID: 37012517
- Novel OX40 and 4-1BB derived spacers enhance CD30 CAR activity and safety in CD30 positive lymphoma models. | Kua, L., et al. 2024. Mol Ther. 32: 3504-3521. PMID: 38946142
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ox40 Antibody (6A371) | sc-71769 | 200 µg/ml | $316.00 | |||
Ox40 Antibody (6A371) FITC | sc-71769 FITC | 200 µg/ml | $330.00 | |||
Ox40 Antibody (6A371) PE | sc-71769 PE | 200 µg/ml | $343.00 |